Bisphenol A inhibits penile erection via alteration of histology in the rabbit

D. G. Moon, D. J. Sung, Y. S. Kim, J. Cheon, J. J. Kim

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)

    Abstract

    Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative dose of 900 mg/kg). Four and 8 weeks after administration of BPA, the contractions and relaxation of cavernosal tissue strips were significantly suppressed in the BPA-treated animals compared to the control animals. Histologically, thickening of tunica albuginea, subtunical deposition of fat and decreased sinusoidal space with consequent increase of trabecular smooth muscle content were observed in the BPA-treated animals. These results suggest that xenoestrogen BPA may affect the erectile function through evident histological changes of the penis.

    Original languageEnglish
    Pages (from-to)309-316
    Number of pages8
    JournalInternational Journal of Impotence Research
    Volume13
    Issue number5
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Bisphenol A
    • Erection
    • Penis
    • Xenoestrogen

    ASJC Scopus subject areas

    • Urology

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