Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial

Han Saem Jeong, Sohyeon Kim, Soon Jun Hong, Seung Cheol Choi, Ji Hyun Choi, Jong Ho Kim, Chi Yeon Park, Jae Young Cho, Tae Bum Lee, Ji Wung Kwon, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim

Research output: Contribution to journalArticle

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Abstract

Administration of black raspberry (Rubus occidentalis) is known to improve vascular endothelial function in patients at a high risk for cardiovascular (CV) disease. We investigated short-term effects of black raspberry on circulating endothelial progenitor cells (EPCs) and arterial stiffness in patients with metabolic syndrome. Patients with metabolic syndrome (n = 51) were prospectively randomized into the black raspberry group (n = 26, 750 mg/day) and placebo group (n = 25) during the 12-week follow-up. Central blood pressure, augmentation index, and EPCs, such as CD34/KDR+, CD34/CD117+, and CD34/CD133+, were measured at baseline and at 12-week follow-up. Radial augmentation indexes were significantly decreased in the black raspberry group compared to the placebo group (-5% ± 10% vs. 3% ± 14%, P <.05). CD34/CD133+ cells at 12-week follow-up were significantly higher in the black raspberry group compared to the placebo group (19 ± 109/μL vs.-28 ± 57/μL, P <.05). Decreases from the baseline in interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were significantly greater in the black raspberry group compared to the placebo group (-0.5 ± 1.4 pg/mL vs.-0.1 ± 1.1 pg/mL, P <.05 and-5.4 ± 4.5 pg/mL vs.-0.8 ± 4.0 pg/mL, P <.05, respectively). Increases from the baseline in adiponectin levels (2.9 ± 2.1 μg/mL vs.-0.2 ± 2.5 μg/mL, P <.05) were significant in the black raspberry group. The use of black raspberry significantly lowered the augmentation index and increased circulating EPCs, thereby improving CV risks in patients with metabolic syndrome during the 12-week follow-up.

Original languageEnglish
Pages (from-to)346-352
Number of pages7
JournalJournal of Medicinal Food
Volume19
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

Fingerprint

Vascular Stiffness
Randomized Controlled Trials
Placebos
Rubus
Endothelial Progenitor Cells
Adiponectin
Blood Vessels
Interleukin-6
Cardiovascular Diseases
Tumor Necrosis Factor-alpha
Blood Pressure

Keywords

  • augmentation index
  • black raspberry
  • central blood pressure
  • endothelial progenitor cells
  • metabolic syndrome

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome : A Randomized Controlled Trial. / Jeong, Han Saem; Kim, Sohyeon; Hong, Soon Jun; Choi, Seung Cheol; Choi, Ji Hyun; Kim, Jong Ho; Park, Chi Yeon; Cho, Jae Young; Lee, Tae Bum; Kwon, Ji Wung; Joo, Hyung Joon; Park, Jae Hyoung; Yu, Cheol Woong; Lim, Do-Sun.

In: Journal of Medicinal Food, Vol. 19, No. 4, 01.04.2016, p. 346-352.

Research output: Contribution to journalArticle

Jeong, Han Saem ; Kim, Sohyeon ; Hong, Soon Jun ; Choi, Seung Cheol ; Choi, Ji Hyun ; Kim, Jong Ho ; Park, Chi Yeon ; Cho, Jae Young ; Lee, Tae Bum ; Kwon, Ji Wung ; Joo, Hyung Joon ; Park, Jae Hyoung ; Yu, Cheol Woong ; Lim, Do-Sun. / Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome : A Randomized Controlled Trial. In: Journal of Medicinal Food. 2016 ; Vol. 19, No. 4. pp. 346-352.
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