Blockade of peroxynitrite-mediated astrocyte death by manganese(III)-cyclam

Young Choi, Youngnam Jin, Wonwoo Nam, Hyoung Chun Kim, Won Ki Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Under glucose-deprived conditions, astrocytes rapidly underwent death due to their increased susceptibility to endogenously produced peroxynitrite (Gila 31, 155-164; J. Neuroimmunol. 112, 55-62; J. Neurochem. 74, 1989-1998). In the present study, the cell membrane-permeable synthetic superoxide dismutase (SOD) mimetic cyclam manganese(III) 1,4,8,11-tetraazacyclodecane (Mn(III)-cyclam) completely inhibited the death of glucose-deprived immunostimulated astrocytes. However, the structurally related compounds Ni(II)-cyclam, Co(II)-cyclam, and H2-cyclam, which lacks metals, had no or a little cytoprotective effect. Of the cyclams used in this study, only Mn(III)-cyclam completely scavenged the peroxynitrite produced in glucose-deprived immunostimulated astrocytes and significantly blocked the depolarization of mitochondrial transmembrane potential in those cells. The present results suggest that cell membrane-permeable synthetic SOD mimetics such as Mn(III)-cyclam may be potential therapeutic agents for various diseases associated with the endogenous production of peroxynitrite.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalNeuroscience Research
Volume45
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1
Externally publishedYes

Keywords

  • Glucose deprivation
  • Immunostimulation
  • Mitochondria transmembrane potential
  • Mn(III)-cyclam

ASJC Scopus subject areas

  • Neuroscience(all)

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