Abstract
PWV, a surrogate marker for vascular stiffness, can be also expressed by the Bramwell-Hill equation. The effect of blood density to PWV has been ignored, because variation of blood density is assumed to be negligible. In some clinical situation, blood density could be changed, and blood density as a mechanical property of blood flow might affect to PWV. While the elastic property plays an important role in determining the wave propagation in an elastic tube, our assumption is that there might be some relation between blood flow and vascular wall, and that the characteristics of blood flow might influence PWV. This study was objected to investigate the role of mechanical and hemorheologic parameters on PWV in subjects with cardiovascular disease. We have measured and analyzed the PWV, hemorheologic parameters, and other clinical parameters in 814 patients with coronary arterial disease scheduled for coronary angiography. There is no commercial method for measuring whole blood density. So, we defined the density score, which is sum of hemoglobin and total protein. And the hemorheologic parameters were measured within 4 hours after sampling by automated microfluidic hemorheometer. And the effect of all the clinical and hemorheologic parameter on PWV was analyzed by multiple linear regression analysis. Many clinical parameters including age and blood pressure, high shear WBV and ESR as hemorheologic parameters, and density score were correlated well with ba-PWV. However, many clinical variables, high shear WBV and ESR lost the independent significance on multivariable regression analysis. Only age, SBP, and density score were independent variables (p < 0.001). In conclusion, density score as a mechanical property of blood might be suggested as an independent variable influencing PWV in addition to age and blood pressure, but hemorheologic parameters, such as RBC deformability, aggregation, and whole blood viscosity do not affect PWV independently.
| Original language | English |
|---|---|
| Pages (from-to) | 193-203 |
| Number of pages | 11 |
| Journal | Clinical Hemorheology and Microcirculation |
| Volume | 55 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 Nov 25 |
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Keywords
- blood density
- pulse wave velocity
- Vascular stiffness
ASJC Scopus subject areas
- Hematology
- Physiology
- Physiology (medical)
- Cardiology and Cardiovascular Medicine
Cite this
Blood characteristics effect on pulse wave velocity. / Kim, Jong Youn; Yoon, Jihyun; Cho, Minhee; Lee, Byoung Kwon; Karimi, Ali; Shin, Sehyun.
In: Clinical Hemorheology and Microcirculation, Vol. 55, No. 1, 25.11.2013, p. 193-203.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blood characteristics effect on pulse wave velocity
AU - Kim, Jong Youn
AU - Yoon, Jihyun
AU - Cho, Minhee
AU - Lee, Byoung Kwon
AU - Karimi, Ali
AU - Shin, Sehyun
PY - 2013/11/25
Y1 - 2013/11/25
N2 - PWV, a surrogate marker for vascular stiffness, can be also expressed by the Bramwell-Hill equation. The effect of blood density to PWV has been ignored, because variation of blood density is assumed to be negligible. In some clinical situation, blood density could be changed, and blood density as a mechanical property of blood flow might affect to PWV. While the elastic property plays an important role in determining the wave propagation in an elastic tube, our assumption is that there might be some relation between blood flow and vascular wall, and that the characteristics of blood flow might influence PWV. This study was objected to investigate the role of mechanical and hemorheologic parameters on PWV in subjects with cardiovascular disease. We have measured and analyzed the PWV, hemorheologic parameters, and other clinical parameters in 814 patients with coronary arterial disease scheduled for coronary angiography. There is no commercial method for measuring whole blood density. So, we defined the density score, which is sum of hemoglobin and total protein. And the hemorheologic parameters were measured within 4 hours after sampling by automated microfluidic hemorheometer. And the effect of all the clinical and hemorheologic parameter on PWV was analyzed by multiple linear regression analysis. Many clinical parameters including age and blood pressure, high shear WBV and ESR as hemorheologic parameters, and density score were correlated well with ba-PWV. However, many clinical variables, high shear WBV and ESR lost the independent significance on multivariable regression analysis. Only age, SBP, and density score were independent variables (p < 0.001). In conclusion, density score as a mechanical property of blood might be suggested as an independent variable influencing PWV in addition to age and blood pressure, but hemorheologic parameters, such as RBC deformability, aggregation, and whole blood viscosity do not affect PWV independently.
AB - PWV, a surrogate marker for vascular stiffness, can be also expressed by the Bramwell-Hill equation. The effect of blood density to PWV has been ignored, because variation of blood density is assumed to be negligible. In some clinical situation, blood density could be changed, and blood density as a mechanical property of blood flow might affect to PWV. While the elastic property plays an important role in determining the wave propagation in an elastic tube, our assumption is that there might be some relation between blood flow and vascular wall, and that the characteristics of blood flow might influence PWV. This study was objected to investigate the role of mechanical and hemorheologic parameters on PWV in subjects with cardiovascular disease. We have measured and analyzed the PWV, hemorheologic parameters, and other clinical parameters in 814 patients with coronary arterial disease scheduled for coronary angiography. There is no commercial method for measuring whole blood density. So, we defined the density score, which is sum of hemoglobin and total protein. And the hemorheologic parameters were measured within 4 hours after sampling by automated microfluidic hemorheometer. And the effect of all the clinical and hemorheologic parameter on PWV was analyzed by multiple linear regression analysis. Many clinical parameters including age and blood pressure, high shear WBV and ESR as hemorheologic parameters, and density score were correlated well with ba-PWV. However, many clinical variables, high shear WBV and ESR lost the independent significance on multivariable regression analysis. Only age, SBP, and density score were independent variables (p < 0.001). In conclusion, density score as a mechanical property of blood might be suggested as an independent variable influencing PWV in addition to age and blood pressure, but hemorheologic parameters, such as RBC deformability, aggregation, and whole blood viscosity do not affect PWV independently.
KW - blood density
KW - pulse wave velocity
KW - Vascular stiffness
UR - http://www.scopus.com/inward/record.url?scp=84887951103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887951103&partnerID=8YFLogxK
U2 - 10.3233/CH-131702
DO - 10.3233/CH-131702
M3 - Article
C2 - 23445636
AN - SCOPUS:84887951103
VL - 55
SP - 193
EP - 203
JO - Clinical Hemorheology and Microcirculation
JF - Clinical Hemorheology and Microcirculation
SN - 1386-0291
IS - 1
ER -