Blood characteristics effect on pulse wave velocity

Jong Youn Kim, Jihyun Yoon, Minhee Cho, Byoung Kwon Lee, Ali Karimi, Sehyun Shin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

PWV, a surrogate marker for vascular stiffness, can be also expressed by the Bramwell-Hill equation. The effect of blood density to PWV has been ignored, because variation of blood density is assumed to be negligible. In some clinical situation, blood density could be changed, and blood density as a mechanical property of blood flow might affect to PWV. While the elastic property plays an important role in determining the wave propagation in an elastic tube, our assumption is that there might be some relation between blood flow and vascular wall, and that the characteristics of blood flow might influence PWV. This study was objected to investigate the role of mechanical and hemorheologic parameters on PWV in subjects with cardiovascular disease. We have measured and analyzed the PWV, hemorheologic parameters, and other clinical parameters in 814 patients with coronary arterial disease scheduled for coronary angiography. There is no commercial method for measuring whole blood density. So, we defined the density score, which is sum of hemoglobin and total protein. And the hemorheologic parameters were measured within 4 hours after sampling by automated microfluidic hemorheometer. And the effect of all the clinical and hemorheologic parameter on PWV was analyzed by multiple linear regression analysis. Many clinical parameters including age and blood pressure, high shear WBV and ESR as hemorheologic parameters, and density score were correlated well with ba-PWV. However, many clinical variables, high shear WBV and ESR lost the independent significance on multivariable regression analysis. Only age, SBP, and density score were independent variables (p < 0.001). In conclusion, density score as a mechanical property of blood might be suggested as an independent variable influencing PWV in addition to age and blood pressure, but hemorheologic parameters, such as RBC deformability, aggregation, and whole blood viscosity do not affect PWV independently.

Original languageEnglish
Pages (from-to)193-203
Number of pages11
JournalClinical Hemorheology and Microcirculation
Volume55
Issue number1
DOIs
Publication statusPublished - 2013 Nov 25

Fingerprint

Pulse Wave Analysis
Regression Analysis
Blood Viscosity
Vascular Stiffness
Microfluidics
Coronary Angiography
Coronary Disease
Blood Vessels
Linear Models
Hemoglobins
Cardiovascular Diseases
Biomarkers
Blood Pressure
Hypertension

Keywords

  • blood density
  • pulse wave velocity
  • Vascular stiffness

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Blood characteristics effect on pulse wave velocity. / Kim, Jong Youn; Yoon, Jihyun; Cho, Minhee; Lee, Byoung Kwon; Karimi, Ali; Shin, Sehyun.

In: Clinical Hemorheology and Microcirculation, Vol. 55, No. 1, 25.11.2013, p. 193-203.

Research output: Contribution to journalArticle

Kim, Jong Youn ; Yoon, Jihyun ; Cho, Minhee ; Lee, Byoung Kwon ; Karimi, Ali ; Shin, Sehyun. / Blood characteristics effect on pulse wave velocity. In: Clinical Hemorheology and Microcirculation. 2013 ; Vol. 55, No. 1. pp. 193-203.
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AB - PWV, a surrogate marker for vascular stiffness, can be also expressed by the Bramwell-Hill equation. The effect of blood density to PWV has been ignored, because variation of blood density is assumed to be negligible. In some clinical situation, blood density could be changed, and blood density as a mechanical property of blood flow might affect to PWV. While the elastic property plays an important role in determining the wave propagation in an elastic tube, our assumption is that there might be some relation between blood flow and vascular wall, and that the characteristics of blood flow might influence PWV. This study was objected to investigate the role of mechanical and hemorheologic parameters on PWV in subjects with cardiovascular disease. We have measured and analyzed the PWV, hemorheologic parameters, and other clinical parameters in 814 patients with coronary arterial disease scheduled for coronary angiography. There is no commercial method for measuring whole blood density. So, we defined the density score, which is sum of hemoglobin and total protein. And the hemorheologic parameters were measured within 4 hours after sampling by automated microfluidic hemorheometer. And the effect of all the clinical and hemorheologic parameter on PWV was analyzed by multiple linear regression analysis. Many clinical parameters including age and blood pressure, high shear WBV and ESR as hemorheologic parameters, and density score were correlated well with ba-PWV. However, many clinical variables, high shear WBV and ESR lost the independent significance on multivariable regression analysis. Only age, SBP, and density score were independent variables (p < 0.001). In conclusion, density score as a mechanical property of blood might be suggested as an independent variable influencing PWV in addition to age and blood pressure, but hemorheologic parameters, such as RBC deformability, aggregation, and whole blood viscosity do not affect PWV independently.

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