Blood-compatible bio-inspired surface of poly(L-lactide-co-ε-caprolactone) films prepared using poor co-solvent casting

Jin Ik Lim, Soo Hyun Kim

Research output: Contribution to journalArticle

Abstract

Simple poor-cosolvent casting was used to surface treat biodegradable elastic poly(L-lactide-co-ε-caprolactone) (PLCL; 50:50) copolymer films that presented lotus-leaf-like structures. We evaluated whether the lotus-leaf-like-structured PLCL (L-PLCL) films could be used as a biomaterial for artificial vascular grafts. The surface morphology, hydrophobicity, and antithrombotic efficiency of the films were examined while immersed in platelet-rich plasma (PRP) using scanning electron microscopy (SEM) and a contact angle meter. The recovery and crystallinity of the films were measured using a tensile-strength testing machine and an X-ray diffractometer, respectively. The solvent containing acetic acid, as a poor co-solvent, and methylene chloride mixed in a 1:2 ratio produced an optimal PLCL film with a water contact angle of approximately 124°. Furthermore, the surface of the L-PLCL films immersed in PRP showed a lower rate of platelet adhesion (<10%) than that of the surface of an untreated PLCL film immersed in PRP.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalPolymer (Korea)
Volume39
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Casting
Blood
Platelets
Plasmas
Contact angle
Methylene Chloride
Dichloromethane
Diffractometers
Biocompatible Materials
Hydrophobicity
poly(lactide)
caprolactone
Biomaterials
Acetic acid
Grafts
Acetic Acid
Surface morphology
Tensile strength
Adhesion
Copolymers

Keywords

  • Antithrombotic material
  • Blood vessel
  • Co-solvent system
  • Lotus-leaf-like structure
  • Suface modification

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Blood-compatible bio-inspired surface of poly(L-lactide-co-ε-caprolactone) films prepared using poor co-solvent casting. / Lim, Jin Ik; Kim, Soo Hyun.

In: Polymer (Korea), Vol. 39, No. 1, 01.01.2015, p. 40-45.

Research output: Contribution to journalArticle

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