Blood eicosapentaenoic acid and docosahexaenoic acid as predictors of all-cause mortality in patients with acute myocardial infarction - Data from infarction prognosis study (IPS) registry

Sang Hak Lee, Min-Jeong Shin, Jung Sun Kim, Young Guk Ko, Seok Min Kang, Donghoon Choi, Yangsoo Jang, Namsik Chung, Won Heum Shim, Seung Yun Cho, Ichiro Manabe, Jong Won Ha

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Although ω-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases, their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). Methods and Results: The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (% of total fatty acids), were measured in 508 patients (365 males; mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1%) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29, P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. Conclusions: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients.

Original languageEnglish
Pages (from-to)2250-2257
Number of pages8
JournalCirculation Journal
Volume73
Issue number12
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Eicosapentaenoic Acid
Docosahexaenoic Acids
Infarction
Registries
Myocardial Infarction
Mortality
Renal Insufficiency
Confounding Factors (Epidemiology)
Unsaturated Fatty Acids
Proportional Hazards Models
Angiotensin-Converting Enzyme Inhibitors
Phospholipids
Cardiovascular Diseases
Fatty Acids
Biomarkers

Keywords

  • ω-3 fatty acids
  • Death
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Blood eicosapentaenoic acid and docosahexaenoic acid as predictors of all-cause mortality in patients with acute myocardial infarction - Data from infarction prognosis study (IPS) registry. / Lee, Sang Hak; Shin, Min-Jeong; Kim, Jung Sun; Ko, Young Guk; Kang, Seok Min; Choi, Donghoon; Jang, Yangsoo; Chung, Namsik; Shim, Won Heum; Cho, Seung Yun; Manabe, Ichiro; Ha, Jong Won.

In: Circulation Journal, Vol. 73, No. 12, 01.12.2009, p. 2250-2257.

Research output: Contribution to journalArticle

Lee, Sang Hak ; Shin, Min-Jeong ; Kim, Jung Sun ; Ko, Young Guk ; Kang, Seok Min ; Choi, Donghoon ; Jang, Yangsoo ; Chung, Namsik ; Shim, Won Heum ; Cho, Seung Yun ; Manabe, Ichiro ; Ha, Jong Won. / Blood eicosapentaenoic acid and docosahexaenoic acid as predictors of all-cause mortality in patients with acute myocardial infarction - Data from infarction prognosis study (IPS) registry. In: Circulation Journal. 2009 ; Vol. 73, No. 12. pp. 2250-2257.
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abstract = "Background: Although ω-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases, their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). Methods and Results: The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ({\%} of total fatty acids), were measured in 508 patients (365 males; mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1{\%}) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29, P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. Conclusions: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients.",
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T1 - Blood eicosapentaenoic acid and docosahexaenoic acid as predictors of all-cause mortality in patients with acute myocardial infarction - Data from infarction prognosis study (IPS) registry

AU - Lee, Sang Hak

AU - Shin, Min-Jeong

AU - Kim, Jung Sun

AU - Ko, Young Guk

AU - Kang, Seok Min

AU - Choi, Donghoon

AU - Jang, Yangsoo

AU - Chung, Namsik

AU - Shim, Won Heum

AU - Cho, Seung Yun

AU - Manabe, Ichiro

AU - Ha, Jong Won

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Background: Although ω-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases, their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). Methods and Results: The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (% of total fatty acids), were measured in 508 patients (365 males; mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1%) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29, P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. Conclusions: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients.

AB - Background: Although ω-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases, their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). Methods and Results: The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (% of total fatty acids), were measured in 508 patients (365 males; mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1%) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29, P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. Conclusions: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients.

KW - ω-3 fatty acids

KW - Death

KW - Docosahexaenoic acid

KW - Eicosapentaenoic acid

KW - Myocardial infarction

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