Blood eosinophil count as a prognostic biomarker in COPD

Yeon Mok Oh, Keu Sung Lee, Yoonki Hong, Sung Chul Hwang, Jae Yeol Kim, Deog Keom Kim, Kwang Ha Yoo, Ji Hyun Lee, Tae Hyung Kim, Seong Yong Lim, Chin Kook Rhee, Hyoung Kyu Yoon, Sang Yeub Lee, Yong Bum Park, Jin Hee Jung, Woo Jin Kim, Sang Do Lee, Joo Hun Park

Research output: Contribution to journalArticle

Abstract

Background: High blood eosinophil count is a predictive biomarker for response to inhaled corticosteroids in prevention of acute exacerbation of COPD, and low blood eosinophil count is associated with pneumonia risk in COPD patients taking inhaled corticosteroids. However, the prognostic role of blood eosinophil count remains underexplored. Therefore, we investigated the associated factors and mortality based on blood eosinophil count in COPD. Methods: Patients with COPD were recruited from 16 hospitals of the Korean Obstructive Lung Disease cohort (n=395) and COPD in Dusty Area cohort (n=234) of Kangwon University Hospital. The two merged cohorts were divided based on blood eosinophil count into three groups: high (≥5%), middle (2%-5%), and low (<2%). Results: The high group had longer six-minute walk distance (high =445.8±81.4, middle =428.5±88.0, and low =414.7±86.3 m), higher body mass index (23.3±3.1, 23.1±3.1, and 22.5±3.2 kg/m2), lower emphysema index (18.5±14.1, 22.2±15.3, and 23.7±16.3), and higher inspiratory capacity/total lung capacity ratio (32.6±7.4, 32.4±9.2, and 29.9% ± 8.9%) (P<0.05). The survival period increased with increasing blood eosinophil count (high =9.52±0.23, middle =8.47±1.94, and low =7.42±0.27 years, P<0.05). Multivariate linear regression analysis revealed that the emphysema index was independently and negatively correlated with blood eosinophil count (P<0.05). Conclusion: In COPD, the severity of emphysema was independently linked with low blood eosinophil count and the longer survival period was associated with increased blood eosinophil count, though it was not proven in the multivariate analysis.

Original languageEnglish
Pages (from-to)3589-3596
Number of pages8
JournalInternational journal of chronic obstructive pulmonary disease
Volume13
DOIs
Publication statusPublished - 2018 Jan 1

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Eosinophils
Chronic Obstructive Pulmonary Disease
Biomarkers
Emphysema
Adrenal Cortex Hormones
Inspiratory Capacity
Total Lung Capacity
Obstructive Lung Diseases
Survival
Linear Models
Pneumonia
Body Mass Index
Multivariate Analysis
Regression Analysis
Mortality

Keywords

  • biomarker
  • blood eosinophil
  • COPD

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

Oh, Y. M., Lee, K. S., Hong, Y., Hwang, S. C., Kim, J. Y., Kim, D. K., ... Park, J. H. (2018). Blood eosinophil count as a prognostic biomarker in COPD. International journal of chronic obstructive pulmonary disease, 13, 3589-3596. https://doi.org/10.2147/COPD.S179734

Blood eosinophil count as a prognostic biomarker in COPD. / Oh, Yeon Mok; Lee, Keu Sung; Hong, Yoonki; Hwang, Sung Chul; Kim, Jae Yeol; Kim, Deog Keom; Yoo, Kwang Ha; Lee, Ji Hyun; Kim, Tae Hyung; Lim, Seong Yong; Rhee, Chin Kook; Yoon, Hyoung Kyu; Lee, Sang Yeub; Park, Yong Bum; Jung, Jin Hee; Kim, Woo Jin; Lee, Sang Do; Park, Joo Hun.

In: International journal of chronic obstructive pulmonary disease, Vol. 13, 01.01.2018, p. 3589-3596.

Research output: Contribution to journalArticle

Oh, YM, Lee, KS, Hong, Y, Hwang, SC, Kim, JY, Kim, DK, Yoo, KH, Lee, JH, Kim, TH, Lim, SY, Rhee, CK, Yoon, HK, Lee, SY, Park, YB, Jung, JH, Kim, WJ, Lee, SD & Park, JH 2018, 'Blood eosinophil count as a prognostic biomarker in COPD', International journal of chronic obstructive pulmonary disease, vol. 13, pp. 3589-3596. https://doi.org/10.2147/COPD.S179734
Oh, Yeon Mok ; Lee, Keu Sung ; Hong, Yoonki ; Hwang, Sung Chul ; Kim, Jae Yeol ; Kim, Deog Keom ; Yoo, Kwang Ha ; Lee, Ji Hyun ; Kim, Tae Hyung ; Lim, Seong Yong ; Rhee, Chin Kook ; Yoon, Hyoung Kyu ; Lee, Sang Yeub ; Park, Yong Bum ; Jung, Jin Hee ; Kim, Woo Jin ; Lee, Sang Do ; Park, Joo Hun. / Blood eosinophil count as a prognostic biomarker in COPD. In: International journal of chronic obstructive pulmonary disease. 2018 ; Vol. 13. pp. 3589-3596.
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abstract = "Background: High blood eosinophil count is a predictive biomarker for response to inhaled corticosteroids in prevention of acute exacerbation of COPD, and low blood eosinophil count is associated with pneumonia risk in COPD patients taking inhaled corticosteroids. However, the prognostic role of blood eosinophil count remains underexplored. Therefore, we investigated the associated factors and mortality based on blood eosinophil count in COPD. Methods: Patients with COPD were recruited from 16 hospitals of the Korean Obstructive Lung Disease cohort (n=395) and COPD in Dusty Area cohort (n=234) of Kangwon University Hospital. The two merged cohorts were divided based on blood eosinophil count into three groups: high (≥5{\%}), middle (2{\%}-5{\%}), and low (<2{\%}). Results: The high group had longer six-minute walk distance (high =445.8±81.4, middle =428.5±88.0, and low =414.7±86.3 m), higher body mass index (23.3±3.1, 23.1±3.1, and 22.5±3.2 kg/m2), lower emphysema index (18.5±14.1, 22.2±15.3, and 23.7±16.3), and higher inspiratory capacity/total lung capacity ratio (32.6±7.4, 32.4±9.2, and 29.9{\%} ± 8.9{\%}) (P<0.05). The survival period increased with increasing blood eosinophil count (high =9.52±0.23, middle =8.47±1.94, and low =7.42±0.27 years, P<0.05). Multivariate linear regression analysis revealed that the emphysema index was independently and negatively correlated with blood eosinophil count (P<0.05). Conclusion: In COPD, the severity of emphysema was independently linked with low blood eosinophil count and the longer survival period was associated with increased blood eosinophil count, though it was not proven in the multivariate analysis.",
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T1 - Blood eosinophil count as a prognostic biomarker in COPD

AU - Oh, Yeon Mok

AU - Lee, Keu Sung

AU - Hong, Yoonki

AU - Hwang, Sung Chul

AU - Kim, Jae Yeol

AU - Kim, Deog Keom

AU - Yoo, Kwang Ha

AU - Lee, Ji Hyun

AU - Kim, Tae Hyung

AU - Lim, Seong Yong

AU - Rhee, Chin Kook

AU - Yoon, Hyoung Kyu

AU - Lee, Sang Yeub

AU - Park, Yong Bum

AU - Jung, Jin Hee

AU - Kim, Woo Jin

AU - Lee, Sang Do

AU - Park, Joo Hun

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: High blood eosinophil count is a predictive biomarker for response to inhaled corticosteroids in prevention of acute exacerbation of COPD, and low blood eosinophil count is associated with pneumonia risk in COPD patients taking inhaled corticosteroids. However, the prognostic role of blood eosinophil count remains underexplored. Therefore, we investigated the associated factors and mortality based on blood eosinophil count in COPD. Methods: Patients with COPD were recruited from 16 hospitals of the Korean Obstructive Lung Disease cohort (n=395) and COPD in Dusty Area cohort (n=234) of Kangwon University Hospital. The two merged cohorts were divided based on blood eosinophil count into three groups: high (≥5%), middle (2%-5%), and low (<2%). Results: The high group had longer six-minute walk distance (high =445.8±81.4, middle =428.5±88.0, and low =414.7±86.3 m), higher body mass index (23.3±3.1, 23.1±3.1, and 22.5±3.2 kg/m2), lower emphysema index (18.5±14.1, 22.2±15.3, and 23.7±16.3), and higher inspiratory capacity/total lung capacity ratio (32.6±7.4, 32.4±9.2, and 29.9% ± 8.9%) (P<0.05). The survival period increased with increasing blood eosinophil count (high =9.52±0.23, middle =8.47±1.94, and low =7.42±0.27 years, P<0.05). Multivariate linear regression analysis revealed that the emphysema index was independently and negatively correlated with blood eosinophil count (P<0.05). Conclusion: In COPD, the severity of emphysema was independently linked with low blood eosinophil count and the longer survival period was associated with increased blood eosinophil count, though it was not proven in the multivariate analysis.

AB - Background: High blood eosinophil count is a predictive biomarker for response to inhaled corticosteroids in prevention of acute exacerbation of COPD, and low blood eosinophil count is associated with pneumonia risk in COPD patients taking inhaled corticosteroids. However, the prognostic role of blood eosinophil count remains underexplored. Therefore, we investigated the associated factors and mortality based on blood eosinophil count in COPD. Methods: Patients with COPD were recruited from 16 hospitals of the Korean Obstructive Lung Disease cohort (n=395) and COPD in Dusty Area cohort (n=234) of Kangwon University Hospital. The two merged cohorts were divided based on blood eosinophil count into three groups: high (≥5%), middle (2%-5%), and low (<2%). Results: The high group had longer six-minute walk distance (high =445.8±81.4, middle =428.5±88.0, and low =414.7±86.3 m), higher body mass index (23.3±3.1, 23.1±3.1, and 22.5±3.2 kg/m2), lower emphysema index (18.5±14.1, 22.2±15.3, and 23.7±16.3), and higher inspiratory capacity/total lung capacity ratio (32.6±7.4, 32.4±9.2, and 29.9% ± 8.9%) (P<0.05). The survival period increased with increasing blood eosinophil count (high =9.52±0.23, middle =8.47±1.94, and low =7.42±0.27 years, P<0.05). Multivariate linear regression analysis revealed that the emphysema index was independently and negatively correlated with blood eosinophil count (P<0.05). Conclusion: In COPD, the severity of emphysema was independently linked with low blood eosinophil count and the longer survival period was associated with increased blood eosinophil count, though it was not proven in the multivariate analysis.

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