Blood plasma separation using microfluidic guiding channel in a continuous fashion

Karimi Ali, Honggu Chun, Yang Jun Kang, Gyeong Bok Jung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Since plasma proteins are varied depending on diseases states, its continuous monitoring has been considered as effective diagnostic tool. In this study, a simple and efficient method for separate plasma and red blood cells (RBCs) from blood sample is proposed with a microfluidic device. To separate plasma in continuous way, microfluidic guiding channel is designed by connecting two channels with different heights in parallel, and employs inertial force and Zweifach-Fung bifurcation law. Due to its unique geometry, most RBCs flowed inside wall region with higher height. Then, plasma is collected from center region with lower height. As a result, the efficiency of plasma separation is achieved over 90 %. Furthermore, it is remained constant, even up to high value of 40% hematocrit. In the near future, the proposed method will be integrated with a lab-on-a-chip for diagnosing diseases.

Original languageEnglish
Title of host publicationClinical and Preclinical Optical Diagnostics II
EditorsJ. Quincy Brown, Ton G. van Leeuwen
PublisherSPIE
ISBN (Electronic)9781510628397
DOIs
Publication statusPublished - 2019 Jan 1
EventClinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany
Duration: 2019 Jun 232019 Jun 25

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11073
ISSN (Print)1605-7422

Conference

ConferenceClinical and Preclinical Optical Diagnostics II 2019
CountryGermany
CityMunich
Period19/6/2319/6/25

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Keywords

  • Inertial force
  • Microfluidics
  • Plasma separation
  • Point-of-care diagnosis
  • Zweifach-Fung effect

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Ali, K., Chun, H., Kang, Y. J., & Jung, G. B. (2019). Blood plasma separation using microfluidic guiding channel in a continuous fashion. In J. Q. Brown, & T. G. van Leeuwen (Eds.), Clinical and Preclinical Optical Diagnostics II [110731R] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073). SPIE. https://doi.org/10.1117/12.2526676