Blood plasma separation using microfluidic guiding channel in a continuous fashion

Karimi Ali, Honggu Chun, Yang Jun Kang, Gyeong Bok Jung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Since plasma proteins are varied depending on diseases states, its continuous monitoring has been considered as effective diagnostic tool. In this study, a simple and efficient method for separate plasma and red blood cells (RBCs) from blood sample is proposed with a microfluidic device. To separate plasma in continuous way, microfluidic guiding channel is designed by connecting two channels with different heights in parallel, and employs inertial force and Zweifach-Fung bifurcation law. Due to its unique geometry, most RBCs flowed inside wall region with higher height. Then, plasma is collected from center region with lower height. As a result, the efficiency of plasma separation is achieved over 90 %. Furthermore, it is remained constant, even up to high value of 40% hematocrit. In the near future, the proposed method will be integrated with a lab-on-a-chip for diagnosing diseases.

Original languageEnglish
Title of host publicationClinical and Preclinical Optical Diagnostics II
EditorsJ. Quincy Brown, Ton G. van Leeuwen
PublisherSPIE
ISBN (Electronic)9781510628397
DOIs
Publication statusPublished - 2019 Jan 1
EventClinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany
Duration: 2019 Jun 232019 Jun 25

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11073
ISSN (Print)1605-7422

Conference

ConferenceClinical and Preclinical Optical Diagnostics II 2019
CountryGermany
CityMunich
Period19/6/2319/6/25

Fingerprint

blood plasma
Microfluidics
Blood
Plasmas
Lab-On-A-Chip Devices
erythrocytes
Erythrocytes
Lab-on-a-chip
Bifurcation (mathematics)
hematocrit
Hematocrit
microfluidic devices
Blood Proteins
inertia
Cells
blood
chips
Geometry
Monitoring
proteins

Keywords

  • Inertial force
  • Microfluidics
  • Plasma separation
  • Point-of-care diagnosis
  • Zweifach-Fung effect

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Ali, K., Chun, H., Kang, Y. J., & Jung, G. B. (2019). Blood plasma separation using microfluidic guiding channel in a continuous fashion. In J. Q. Brown, & T. G. van Leeuwen (Eds.), Clinical and Preclinical Optical Diagnostics II [110731R] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073). SPIE. https://doi.org/10.1117/12.2526676

Blood plasma separation using microfluidic guiding channel in a continuous fashion. / Ali, Karimi; Chun, Honggu; Kang, Yang Jun; Jung, Gyeong Bok.

Clinical and Preclinical Optical Diagnostics II. ed. / J. Quincy Brown; Ton G. van Leeuwen. SPIE, 2019. 110731R (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ali, K, Chun, H, Kang, YJ & Jung, GB 2019, Blood plasma separation using microfluidic guiding channel in a continuous fashion. in JQ Brown & TG van Leeuwen (eds), Clinical and Preclinical Optical Diagnostics II., 110731R, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11073, SPIE, Clinical and Preclinical Optical Diagnostics II 2019, Munich, Germany, 19/6/23. https://doi.org/10.1117/12.2526676
Ali K, Chun H, Kang YJ, Jung GB. Blood plasma separation using microfluidic guiding channel in a continuous fashion. In Brown JQ, van Leeuwen TG, editors, Clinical and Preclinical Optical Diagnostics II. SPIE. 2019. 110731R. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2526676
Ali, Karimi ; Chun, Honggu ; Kang, Yang Jun ; Jung, Gyeong Bok. / Blood plasma separation using microfluidic guiding channel in a continuous fashion. Clinical and Preclinical Optical Diagnostics II. editor / J. Quincy Brown ; Ton G. van Leeuwen. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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