TY - GEN
T1 - Blood plasma separation using microfluidic guiding channel in a continuous fashion
AU - Karimi, Ali
AU - Chun, Honggu
AU - Kang, Yang Jun
AU - Jung, Gyeong Bok
N1 - Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A3B03931548).
PY - 2019
Y1 - 2019
N2 - Since plasma proteins are varied depending on diseases states, its continuous monitoring has been considered as effective diagnostic tool. In this study, a simple and efficient method for separate plasma and red blood cells (RBCs) from blood sample is proposed with a microfluidic device. To separate plasma in continuous way, microfluidic guiding channel is designed by connecting two channels with different heights in parallel, and employs inertial force and Zweifach–Fung bifurcation law. Due to its unique geometry, most RBCs flowed inside wall region with higher height. Then, plasma is collected from center region with lower height. As a result, the efficiency of plasma separation is achieved over 90 %. Furthermore, it is remained constant, even up to high value of 40% hematocrit. In the near future, the proposed method will be integrated with a lab-on-a-chip for diagnosing diseases.
AB - Since plasma proteins are varied depending on diseases states, its continuous monitoring has been considered as effective diagnostic tool. In this study, a simple and efficient method for separate plasma and red blood cells (RBCs) from blood sample is proposed with a microfluidic device. To separate plasma in continuous way, microfluidic guiding channel is designed by connecting two channels with different heights in parallel, and employs inertial force and Zweifach–Fung bifurcation law. Due to its unique geometry, most RBCs flowed inside wall region with higher height. Then, plasma is collected from center region with lower height. As a result, the efficiency of plasma separation is achieved over 90 %. Furthermore, it is remained constant, even up to high value of 40% hematocrit. In the near future, the proposed method will be integrated with a lab-on-a-chip for diagnosing diseases.
KW - Inertial force
KW - Microfluidics
KW - Plasma separation
KW - Point-of-care diagnosis
KW - Zweifach-Fung effect
UR - http://www.scopus.com/inward/record.url?scp=85084421906&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084421906&partnerID=8YFLogxK
U2 - 10.1117/12.2526676
DO - 10.1117/12.2526676
M3 - Conference contribution
AN - SCOPUS:85084421906
T3 - Optics InfoBase Conference Papers
BT - European Conference on Biomedical Optics, ECBO_2019
PB - OSA - The Optical Society
T2 - European Conference on Biomedical Optics, ECBO_2019
Y2 - 23 June 2019 through 25 June 2019
ER -