BODIPY-Coumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models

Hoyeon Lee, Zhigang Yang, Youngjin Wi, Tae Woo Kim, Peter Verwilst, Yun Hak Lee, Ga In Han, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

An endoplasmic reticulum (ER) membrane-selective chemosensor composed of BODIPY and coumarin moieties and a long alkyl chain (n-C18) was synthesized. The emission ratio of BODIPY to coumarin depends on the solution viscosity. The probe is localized to the ER membrane and was applied to reveal the reduced ER membrane fluidity under ER stress conditions.

Original languageEnglish
Pages (from-to)2474-2480
Number of pages7
JournalBioconjugate Chemistry
Volume26
Issue number12
DOIs
Publication statusPublished - 2015 Dec 16

Fingerprint

Membrane Fluidity
Endoplasmic Reticulum Stress
Fluidity
Endoplasmic Reticulum
Membranes
Sensors
Viscosity
coumarin
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Organic Chemistry
  • Pharmaceutical Science
  • Biomedical Engineering
  • Pharmacology

Cite this

BODIPY-Coumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models. / Lee, Hoyeon; Yang, Zhigang; Wi, Youngjin; Kim, Tae Woo; Verwilst, Peter; Lee, Yun Hak; Han, Ga In; Kang, Chulhun; Kim, Jong Seung.

In: Bioconjugate Chemistry, Vol. 26, No. 12, 16.12.2015, p. 2474-2480.

Research output: Contribution to journalArticle

Lee, Hoyeon ; Yang, Zhigang ; Wi, Youngjin ; Kim, Tae Woo ; Verwilst, Peter ; Lee, Yun Hak ; Han, Ga In ; Kang, Chulhun ; Kim, Jong Seung. / BODIPY-Coumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models. In: Bioconjugate Chemistry. 2015 ; Vol. 26, No. 12. pp. 2474-2480.
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