BODIPY/Nile-Red-Based Efficient FRET Pair: Selective Assay of Endoplasmic Reticulum Membrane Fluidity

Zhigang Yang, Youngjin Wi, Young Min Yoon, Peter Verwilst, Joo Hee Jang, Tae Woo Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We synthesized a boron-dipyrromethene (BODIPY)/Nile Red hybrid probe capable of selectively recognizing fluidity changes in the endoplasmic reticulum (ER) membrane due to its preferential localization to the ER and strong energy transfer from BODIPY to the Nile Red moiety, emitting only in nonaqueous environments. ER membrane fluidity in HepG2 cells was markedly reduced by a cell model of metabolic syndrome.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalChemistry - An Asian Journal
Volume11
Issue number4
DOIs
Publication statusPublished - 2016 Feb 18

Keywords

  • endoplasmic reticulum
  • fluorescence
  • FRET
  • membrane fluidity
  • metabolic syndrome

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'BODIPY/Nile-Red-Based Efficient FRET Pair: Selective Assay of Endoplasmic Reticulum Membrane Fluidity'. Together they form a unique fingerprint.

  • Cite this