Body Cavity-Based Lymphoma in a Country with Low Human Immunodeficiency Virus Prevalence: A Series of 17 Cases from the Consortium for Improving Survival of Lymphoma

Junghoon Shin, Young Hyeh Ko, Sung Yon Oh, Dok Hyun Yoon, Jeong Ok Lee, Jin Seok Kim, Yong Park, Ho Jin Shin, Seok Jin Kim, Jong Ho Won, Sung Soo Yoon, Won Seog Kim, Youngil Koh

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3 Citations (Scopus)

Abstract

Original Article Purpose Primary effusion lymphoma (PEL) is a type of body cavity-based lymphoma (BCBL). Most patients with PEL are severely immunocompromised and seropositive for human immunodeficiency virus (HIV). We investigated the distinctive clinicopathologic characteristics of BCBL in a country with low HIV burden. Materials and Methods We retrospectively collected data on the clinicopathologic characteristics, treatments, and outcomes of 17 consecutive patients with BCBL at nine institutions in Korea. Results Latency-associated nuclear antigen 1 (LANA1) immunostaining indicated that six patients had PEL, six patients had human herpesvirus 8 (HHV8)-unrelated BCBL, and five patients had HHV8-unknown BCBL. The patients with PEL exhibited no evidence of immunodeficiency except for one who was HIV positive. One (20%) and four (80%) patients with PEL and six (100%) and zero (0%) patients with HHV8-unrelated BCBL were positive for CD20 and CD30 expression, respectively. The two patients with PEL (one HIV-positive and one HIV-negative patient) with the lowest proliferation activity as assessed by the Ki-67 labeling index survived for > 1 and > 4 years without chemotherapy, respectively, in contrast to the PEL cases in the literature, which mostly showed a high proliferation index and poor survival. Conclusion PEL mostly occurred in ostensibly immunocompetent individuals and had a favorable outcome in Korea. A watchful waiting approach may be applicable for managing HIV-seronegative patients with PEL with a low Ki-67 labeling index. A possible trend was detected among LANA1, CD20, and CD30 expression in BCBL.

Original languageEnglish
Pages (from-to)1302-1312
Number of pages11
JournalCancer Research and Treatment
Volume51
Issue number4
DOIs
Publication statusPublished - 2019

Keywords

  • Body cavity-based lymphoma
  • Human herpesvirus 8
  • Human immunodeficiency virus
  • Immunophenotype
  • Primary effusion lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Shin, J., Ko, Y. H., Oh, S. Y., Yoon, D. H., Lee, J. O., Kim, J. S., Park, Y., Shin, H. J., Kim, S. J., Won, J. H., Yoon, S. S., Kim, W. S., & Koh, Y. (2019). Body Cavity-Based Lymphoma in a Country with Low Human Immunodeficiency Virus Prevalence: A Series of 17 Cases from the Consortium for Improving Survival of Lymphoma. Cancer Research and Treatment, 51(4), 1302-1312. https://doi.org/10.4143/crt.2018.555