Body size phenotypes and low muscle mass: The Korean sarcopenic obesity study (KSOS)

Tae Nyun Kim, Man Sik Park, Sae Jeong Yang, Hye-Jin Yoo, Hyun Joo Kang, Wook Song, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Context: Unique subsets of body size phenotypes seem to be more prone or more resistant to the development of obesity-associated metabolic disorders, although the underlying mechanism is not yet clearly understood. Objectives: We investigated the prevalence and risk of low muscle mass in subjects who are classified as either metabolically healthy normal weight (MHNW), metabolically abnormal but normal weight (MANW), metabolically healthy obese (MHO), or metabolically abnormal obese (MAO). Subjects were classified based on body mass index and presence of metabolic syndrome. Methods: Thigh muscle cross-sectional area was evaluated using computed tomography as an index of muscle mass in 492 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study (KSOS), an ongoing prospective observational cohort study. Low muscle mass was defined as thigh muscle cross-sectional area divided by weight (percent) of <1 SD below the mean values of young adults in both sexes. Results: The prevalence rates of low muscle mass in MHNW, MANW, MHO, and MAO subjects were 6.2%, 17.8%, 23.2%, and 33.7%, respectively. In a multiple logistic regression analysis, men with the MANW phenotype showed a remarkably increased risk of low muscle mass (odds ratio = 11.30, 95% confidence interval, 1.73-73.28) compared with those with MHNW. Furthermore, in both men and women, MHO or MAO subjects had higher odds ratios of low muscle mass compared with MHNW subjects. Conclusions: The present study suggests that low muscle mass may be associated with different metabolic consequences according to body size phenotype.

Original languageEnglish
Pages (from-to)811-817
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

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Body Size
Muscle
Obesity
Phenotype
Muscles
Weights and Measures
Thigh
Odds Ratio
Regression analysis
Observational Studies
Tomography
Logistics
Young Adult
Body Mass Index
Cohort Studies
Logistic Models
Regression Analysis
Prospective Studies
Confidence Intervals

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Body size phenotypes and low muscle mass : The Korean sarcopenic obesity study (KSOS). / Kim, Tae Nyun; Park, Man Sik; Yang, Sae Jeong; Yoo, Hye-Jin; Kang, Hyun Joo; Song, Wook; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 2, 01.02.2013, p. 811-817.

Research output: Contribution to journalArticle

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abstract = "Context: Unique subsets of body size phenotypes seem to be more prone or more resistant to the development of obesity-associated metabolic disorders, although the underlying mechanism is not yet clearly understood. Objectives: We investigated the prevalence and risk of low muscle mass in subjects who are classified as either metabolically healthy normal weight (MHNW), metabolically abnormal but normal weight (MANW), metabolically healthy obese (MHO), or metabolically abnormal obese (MAO). Subjects were classified based on body mass index and presence of metabolic syndrome. Methods: Thigh muscle cross-sectional area was evaluated using computed tomography as an index of muscle mass in 492 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study (KSOS), an ongoing prospective observational cohort study. Low muscle mass was defined as thigh muscle cross-sectional area divided by weight (percent) of <1 SD below the mean values of young adults in both sexes. Results: The prevalence rates of low muscle mass in MHNW, MANW, MHO, and MAO subjects were 6.2{\%}, 17.8{\%}, 23.2{\%}, and 33.7{\%}, respectively. In a multiple logistic regression analysis, men with the MANW phenotype showed a remarkably increased risk of low muscle mass (odds ratio = 11.30, 95{\%} confidence interval, 1.73-73.28) compared with those with MHNW. Furthermore, in both men and women, MHO or MAO subjects had higher odds ratios of low muscle mass compared with MHNW subjects. Conclusions: The present study suggests that low muscle mass may be associated with different metabolic consequences according to body size phenotype.",
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AU - Kang, Hyun Joo

AU - Song, Wook

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

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