Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model

Kyong Wook Yi, Ramanaiah Mamillapalli, Cagdas Sahin, Jaeyen Song, Reshef Tal, Hugh S. Taylor

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Successful implantation and pregnancy is dependent on sufficient endometrial growth during each reproductive cycle. Here, we report the therapeutic effect of either bone marrow-derived cells (BMDCs) or the stem cell chemo-attractant C-X-C motif chemokine 12 (CXCL12) on endometrial receptivity in a murine ethanol induced thin endometrium model. Endometrial epithelial area was significantly increased in mice treated with BMDCs, CXCL12, or by co-treatment with both compared with PBS-treated controls. Ki-67 and CD31 immunoreactivity was significantly higher in mice treated with either BMDCs, CXCL12, or both. The mRNA expression levels of endometrial receptivity markers leukemia inhibitory factor, interleukin-1β, and integrin beta-3 were increased in mice treated with either BMDCs, CXCL12, or both. The mRNA levels of matrix metalloproteinase-2 and -9 were significantly decreased by BMDCs but not by CXCL12. Pregnancy rates and litter size were increased after either treatment. Both BMDCs and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium. Our findings indicate the potential therapeutic effects of BMDCs and CXCL12 on infertility related to thin endometrium. Bone marrow-derived cells and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalBiology of reproduction
Volume100
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • Bone marrow-derived cells (BMDCs)
  • CXCL12
  • Infertility
  • Thin endometrium

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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