Bone marrow effects of anagrelide therapy in patients with myelofibrosis with myeloid metaplasia

Soo Young Yoon, Chin Yang Li, Ruben A. Mesa, Ayalew Tefferi

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

In a prospective study investigating the therapeutic role of anagrelide in myelofibrosis with myeloid metaplasia, 20 patients received anagrelide in daily oral doses of 0.5-3 mg. 17 patients were evaluable and received anagrelide for a median of 2 years (range 0.5-4 years). No patient had a clinically appreciable benefit. Bone marrow (BM) examinations at baseline and after 6 and 12 months of treatment were available for 17, 17 and 12 patients, respectively. In all evaluable cases, BM megakaryocyte number increased after 6 months of anagrelide treatment. Also, Ulex europaeus agglutinin-1 staining of megakaryocytes revealed a left-shifted maturation pattern in most patients with a platelet response to anagrelide. However, megakaryocyte staining intensity for transforming (TGF-β) and platelet-derived (PDGF) growth factors was not affected consistently by treatment. No patient had a ≥2 grade change in either BM fibrosis or osteosclerosis. These in-vivo data support our previous in-vitro observations that anagrelide interferes with megakaryocyte maturation rather than proliferation. Lack of a positive treatment effect is consistent with the finding that anagrelide did not significantly alter megakaryocyte expression of TGF-β and PDGF.

Original languageEnglish
Pages (from-to)682-688
Number of pages7
JournalBritish Journal of Haematology
Volume106
Issue number3
DOIs
Publication statusPublished - 1999

Keywords

  • Megakaryocytes
  • Platelets

ASJC Scopus subject areas

  • Hematology

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