Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders

Soo-Young Yoon, Chin Yang Li, Ricardo V. Lloyd, Ayalew Tefferi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical analysis is limited. In the current study, bone marrow immunohistochemical staining for platelet-derived growth factor, transforming growth factor (TGF)-β, basic fibroblast growth factor (bFGF), and their receptors was performed in 9 patients with MDS-f, 9 patients with essential thrombocythemia (ET), 8 patients with 5q- syndrome, and 5 healthy control subjects. In addition,TGF-β1 messenger RNA (mRNA) analysis was performed in 5 patients, each with MDS-f, myelofibrosis with myeloid metaplasia (MMM), polycythemia vera (PV), ET, and immune thrombocytopenic purpura, and in healthy control subjects. In general, protein and transcript expression patterns were similar to normal patterns and not significantly different amons the various disease groups. The only exception was a reduced concentration of bFGF-expressing stromal cells in patients with PV, ET, and MMM

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalInternational Journal of Hematology
Volume72
Issue number3
Publication statusPublished - 2000 Dec 1
Externally publishedYes

Fingerprint

Primary Myelofibrosis
Cytokine Receptors
Myelodysplastic Syndromes
Essential Thrombocythemia
Bone Marrow
Polycythemia Vera
Transforming Growth Factors
Fibroblast Growth Factor 2
Healthy Volunteers
Fibroblast Growth Factor Receptors
Idiopathic Thrombocytopenic Purpura
Platelet-Derived Growth Factor
Stromal Cells
Staining and Labeling
Cytokines
Messenger RNA
Proteins

Keywords

  • Chronic myeloid disorders
  • Fibrogenic cytokines
  • Myelodysplastic syndrome with myelofibrosis

ASJC Scopus subject areas

  • Hematology

Cite this

Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders. / Yoon, Soo-Young; Li, Chin Yang; Lloyd, Ricardo V.; Tefferi, Ayalew.

In: International Journal of Hematology, Vol. 72, No. 3, 01.12.2000, p. 337-342.

Research output: Contribution to journalArticle

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