Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

Sun Woong Kang, Wan Geun La, Jin Muk Kang, Jung Ho Park, Byung Soo Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.

Original languageEnglish
Pages (from-to)1163-1168
Number of pages6
JournalBiotechnology letters
Volume30
Issue number7
DOIs
Publication statusPublished - 2008 Jul

Keywords

  • Bone marrow-derived stem cell
  • Bone morphogenetic protein-2
  • Bone regeneration
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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