Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

Sun Woong Kang; Wan Geun La; Jin Muk Kang; Jung Ho Park; Byung Soo Kim

doi:10.1007/s10529-008-9675-8

Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

Sun Woong Kang, Wan Geun La, Jin Muk Kang, Jung Ho Park, Byung Soo Kim

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.

Original language	English
Pages (from-to)	1163-1168
Number of pages	6
Journal	Biotechnology letters
Volume	30
Issue number	7
DOIs	https://doi.org/10.1007/s10529-008-9675-8
Publication status	Published - 2008 Jul
Externally published	Yes

Keywords

Bone marrow-derived stem cell
Bone morphogenetic protein-2
Bone regeneration
Tissue engineering

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1007/s10529-008-9675-8

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title = "Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells",

abstract = "We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.",

keywords = "Bone marrow-derived stem cell, Bone morphogenetic protein-2, Bone regeneration, Tissue engineering",

author = "Kang, {Sun Woong} and La, {Wan Geun} and Kang, {Jin Muk} and Park, {Jung Ho} and Kim, {Byung Soo}",

note = "Funding Information: Acknowledgements This work was supported by a grant (SC 3220) from the Stem Cell Research Center of the 21st Century Frontier Program, which is funded by the Ministry of Science and Technology, Republic of Korea.",

year = "2008",

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doi = "10.1007/s10529-008-9675-8",

language = "English",

volume = "30",

pages = "1163--1168",

journal = "Biotechnology Letters",

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T1 - Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

AU - Kang, Sun Woong

AU - La, Wan Geun

AU - Kang, Jin Muk

AU - Park, Jung Ho

AU - Kim, Byung Soo

N1 - Funding Information: Acknowledgements This work was supported by a grant (SC 3220) from the Stem Cell Research Center of the 21st Century Frontier Program, which is funded by the Ministry of Science and Technology, Republic of Korea.

PY - 2008/7

Y1 - 2008/7

N2 - We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.

AB - We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.

KW - Bone marrow-derived stem cell

KW - Bone morphogenetic protein-2

KW - Bone regeneration

KW - Tissue engineering

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U2 - 10.1007/s10529-008-9675-8

DO - 10.1007/s10529-008-9675-8

M3 - Article

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AN - SCOPUS:44949119587

SN - 0141-5492

VL - 30

SP - 1163

EP - 1168

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 7

ER -

Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

Abstract

Keywords

ASJC Scopus subject areas

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