Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

Sun Woong Kang, Wan Geun La, Jin Muk Kang, Jung-Ho Park, Byung Soo Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.

Original languageEnglish
Pages (from-to)1163-1168
Number of pages6
JournalBiotechnology Letters
Volume30
Issue number7
DOIs
Publication statusPublished - 2008 Jul 1

Fingerprint

Bone Morphogenetic Protein 2
Bone Regeneration
Mesenchymal Stromal Cells
Transplantation
Bone Marrow
Heparin
Osteogenesis
Bone and Bones
polylactic acid-polyglycolic acid copolymer

Keywords

  • Bone marrow-derived stem cell
  • Bone morphogenetic protein-2
  • Bone regeneration
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology

Cite this

Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells. / Kang, Sun Woong; La, Wan Geun; Kang, Jin Muk; Park, Jung-Ho; Kim, Byung Soo.

In: Biotechnology Letters, Vol. 30, No. 7, 01.07.2008, p. 1163-1168.

Research output: Contribution to journalArticle

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