Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats

Hitesh N. Modi, Seung W. Suh, Boopalan Prjvc, Jae Young Hong, Jae Hyuk Yang, Young Hwan Park, Jae Moon Lee, Yong Hyon Kwon

Research output: Contribution to journalArticle

Abstract

Introduction: The purpose of this study was to identify graft osteoporosis post transplantation by micro-CT analysis, and the growth potential of growth plates in the transplanted limb.Methods: Ten juvenile to juvenile and five juvenile to adult hind limb transplants were performed in male syngeneic Lewis rats. Upper tibial bone density in isochronograft and heterochronograft limbs was measured by 3D micro-CT and compared with that of the opposite non-operated limbs.Results: We observed inferior bone quality (p < 0.05) in heterochronografts compared to isochronografts. After transplantation, isochronografts did not exhibit increases in tibial lengths compared to opposite juvenile non-operated tibias (p = 0.66) or heterochronograft tibias (p = 0.61). However, significant differences were observed between heterochrongraft tibial lengths when and opposite adult non operated tibial lengths (p < 0.001).Conclusions: Age dependent alterations affect bone quality, resulting in post transplantation osteoporosis in heterochronografts, but not isochronografts. However, the growth plates of transplanted limbs retain their properties of longitudinal growth and continue to grow at the same rate.

Original languageEnglish
Article number53
JournalJournal of orthopaedic surgery and research
Volume6
Issue number1
DOIs
Publication statusPublished - 2011 Oct 14

Keywords

  • Growth potentials of growth plate
  • Heterochronografts
  • Isochronografts
  • Limb transplant
  • Osteoporosis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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