Borna disease virus and deficit schizophrenia

Yong Ku Kim, Sang Hyun Kim, Changsu Han, Heon-Jeong Lee, Hyung Seob Kim, Sung Chul Yoon, Dai Jin Kim, Ki-Joon Song, Michael Maes, Jin Won Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: It is controversial whether Borna disease virus (BDV) infects humans and causes psychiatric disorders. Objectives: The relationship between BDV infection and schizophrenia with deficit syndrome was investigated. Study design: Using the Schedule for the Deficit Syndrome, 62 schizophrenic in-patients were selected from three psychiatric hospitals. RNA was extracted from peripheral blood mononuclear cells and analyzed using nested reverse transcriptase-polymerase chain reaction with primers to detect BDV p24 and p40. Results and conclusions: BDV transcripts were not detected in samples from any of the 62 schizophrenic patients. These data do not support an etiologic association between BDV infection and the deficit form of schizophrenia.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalActa Neuropsychiatrica
Volume15
Issue number5
DOIs
Publication statusPublished - 2003 Oct 1

Keywords

  • Borna disease virus
  • Deficit syndrome
  • PBMC
  • RT-PCR
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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