Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men

Abhishek Vishnu, Jina Choo, Bradley Wilcox, Takashi Hisamatsu, Emma J M Barinas-Mitchell, Akira Fujiyoshi, Rachel H. Mackey, Aya Kadota, Vasudha Ahuja, Takashi Kadowaki, Daniel Edmundowicz, Katsuyuki Miura, Beatriz L. Rodriguez, Lewis H. Kuller, Chol Shin, Kamal Masaki, Hirotsugu Ueshima, Akira Sekikawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men. Methods: A population-based sample of1131 men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as ≥10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV. Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p < 0.01), or by 36% per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans. Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacksin the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalInternational Journal of Cardiology
Volume189
Issue number1
DOIs
Publication statusPublished - 2015 Jun 15

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Pulse Wave Analysis
Ankle
Arm
Coronary Vessels
Cardiovascular Diseases
Vascular Stiffness
Asian Americans
Far East
Korea
Longitudinal Studies
Coronary Artery Disease
Atherosclerosis
Japan
Odds Ratio
Tomography
Confidence Intervals
Population

Keywords

  • Arteriosclerosis
  • Atherosclerosis
  • Pulse wave analysis
  • Vascular calcification
  • Vascular stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men. / Vishnu, Abhishek; Choo, Jina; Wilcox, Bradley; Hisamatsu, Takashi; Barinas-Mitchell, Emma J M; Fujiyoshi, Akira; Mackey, Rachel H.; Kadota, Aya; Ahuja, Vasudha; Kadowaki, Takashi; Edmundowicz, Daniel; Miura, Katsuyuki; Rodriguez, Beatriz L.; Kuller, Lewis H.; Shin, Chol; Masaki, Kamal; Ueshima, Hirotsugu; Sekikawa, Akira.

In: International Journal of Cardiology, Vol. 189, No. 1, 15.06.2015, p. 67-72.

Research output: Contribution to journalArticle

Vishnu, A, Choo, J, Wilcox, B, Hisamatsu, T, Barinas-Mitchell, EJM, Fujiyoshi, A, Mackey, RH, Kadota, A, Ahuja, V, Kadowaki, T, Edmundowicz, D, Miura, K, Rodriguez, BL, Kuller, LH, Shin, C, Masaki, K, Ueshima, H & Sekikawa, A 2015, 'Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men', International Journal of Cardiology, vol. 189, no. 1, pp. 67-72. https://doi.org/10.1016/j.ijcard.2015.04.020
Vishnu, Abhishek ; Choo, Jina ; Wilcox, Bradley ; Hisamatsu, Takashi ; Barinas-Mitchell, Emma J M ; Fujiyoshi, Akira ; Mackey, Rachel H. ; Kadota, Aya ; Ahuja, Vasudha ; Kadowaki, Takashi ; Edmundowicz, Daniel ; Miura, Katsuyuki ; Rodriguez, Beatriz L. ; Kuller, Lewis H. ; Shin, Chol ; Masaki, Kamal ; Ueshima, Hirotsugu ; Sekikawa, Akira. / Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men. In: International Journal of Cardiology. 2015 ; Vol. 189, No. 1. pp. 67-72.
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abstract = "Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men. Methods: A population-based sample of1131 men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as ≥10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV. Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95{\%} Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19{\%} per 100 cm/s increase (p < 0.01), or by 36{\%} per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans. Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacksin the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability.",
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AU - Vishnu, Abhishek

AU - Choo, Jina

AU - Wilcox, Bradley

AU - Hisamatsu, Takashi

AU - Barinas-Mitchell, Emma J M

AU - Fujiyoshi, Akira

AU - Mackey, Rachel H.

AU - Kadota, Aya

AU - Ahuja, Vasudha

AU - Kadowaki, Takashi

AU - Edmundowicz, Daniel

AU - Miura, Katsuyuki

AU - Rodriguez, Beatriz L.

AU - Kuller, Lewis H.

AU - Shin, Chol

AU - Masaki, Kamal

AU - Ueshima, Hirotsugu

AU - Sekikawa, Akira

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N2 - Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men. Methods: A population-based sample of1131 men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as ≥10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV. Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p < 0.01), or by 36% per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans. Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacksin the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability.

AB - Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men. Methods: A population-based sample of1131 men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as ≥10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV. Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p < 0.01), or by 36% per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans. Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacksin the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability.

KW - Arteriosclerosis

KW - Atherosclerosis

KW - Pulse wave analysis

KW - Vascular calcification

KW - Vascular stiffness

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