Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia

Jieun Shin, Hawon Cho, Sun Wook Hwang, Jooyoung Jung, Chan Young Shin, Soon Youl Lee, So Hee Kim, Myung Gull Lee, Young Hae Choi, Jinwoong Kim, Nicole Alessandri Haber, David B. Reichling, Sachia Khasar, Jon D. Levine, Uhtaek Oh

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300 Citations (Scopus)

Abstract

The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid. This finding identifies a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.

Original languageEnglish
Pages (from-to)10150-10155
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number15
DOIs
Publication statusPublished - 2002 Jul 23
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Shin, J., Cho, H., Hwang, S. W., Jung, J., Shin, C. Y., Lee, S. Y., Kim, S. H., Lee, M. G., Choi, Y. H., Kim, J., Haber, N. A., Reichling, D. B., Khasar, S., Levine, J. D., & Oh, U. (2002). Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 10150-10155. https://doi.org/10.1073/pnas.152002699