Brain magnetic resolution imaging to diagnose Bing-Neel syndrome

Ho Jung Kim, Sang Il Suh, Joo Han Kim, Byung Jo Kim

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)


    Radiologic findings of Bing-Neel syndrome, which is an extremely uncommon complication resulting from malignant lymphocyte infiltration into the central nervous system (CNS) in patients with Waldenström's macroglobulinemia (WM), have been infrequently reported due to extreme rarity of the case. A 75-year-old man with WM presented at a neurology clinic with progressive gait and memory disturbances, and dysarthria of 2 months duration. Cerebrospinal fluid and serum protein electrophoresis and immunofixation electrophoresis showed IgM kappa-type monoclonal gammopathy. Brain magnetic resonance imaging revealed multifocal, hyperintense lesions on T2 weighted-images. Brain diffusion-weighted imaging (DWI) demonstrated hyperintensities in cerebral and cerebellar lesions that appeared isointense on apparent diffusion coefficient maps, which were compatible with vasogenic edema. Although histologic analysis is a confirmative study to prove direct cell infiltration into the brain, brain MRI with DWI may be a good supportive study to diagnose Bing-Neel syndrome.

    Original languageEnglish
    Pages (from-to)588-591
    Number of pages4
    JournalJournal of Korean Neurosurgical Society
    Issue number6
    Publication statusPublished - 2009 Dec


    • Bing-Neel syndrome
    • MRI
    • Waldenström's macroglobulinemia

    ASJC Scopus subject areas

    • Surgery
    • Neuroscience(all)
    • Clinical Neurology


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