Brain-specific chemokine FAM19A5 induces hypothalamic inflammation

Dasol Kang, Han Rae Kim, Kwang Kon Kim, Dong Hee Kim, Bora Jeong, Sungho Jin, Jeong Woo Park, Jae Young Seong, Byung Ju Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The cytokine-like protein FAM19A5 is highly expressed in the brain, but little is known about its functions there. Here, we found that FAM19A5 was expressed in mouse hypothalamic cells expressing proopiomelanocortin (POMC) and neuropeptide Y (NPY)/agouti-related peptide (AgRP), and in the microglia. Tumor necrosis factor-α (TNF-α), which induces inflammatory sickness responses, greatly increased hypothalamic expression of FAM19A5. Knockdown of FAM19A5 expression resulted in decreased TNF-α-induced anorexia, body weight loss and TNF-α-induced expression of inflammatory factors. In contrast, intracerebroventricular administration of FAM19A5 induced anorexia, body weight loss and hyperthermia, together with increased expression of inflammatory factors. FAM19A5 injection also induced increases in c-fos activation and POMC mRNA level in hypothalamic POMC neurons. Together, these results suggest that FAM19A5 plays an important role in hypothalamic inflammatory responses.

Original languageEnglish
Pages (from-to)829-834
Number of pages6
JournalBiochemical and biophysical research communications
Volume523
Issue number4
DOIs
Publication statusPublished - 2020 Mar 19

Keywords

  • Anorexia
  • Hyperthermia
  • Hypothalamic inflammation
  • Proinflammatory cytokines
  • Sickness responses
  • Tumor necrosis factor-α (TNF-α)

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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