Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis

Ming Yi Bai, Jian Xiu Shang, Eunkyoo Oh, Min Fan, Yang Bai, Rodolfo Zentella, Tai Ping Sun, Zhi Yong Wang

Research output: Contribution to journalArticle

325 Citations (Scopus)

Abstract

Brassinosteroid and gibberellin promote many similar developmental responses in plants; however, their relationship remains unclear. Here we show that BR and GA act interdependently through a direct interaction between the BR-Activated BZR1 and GA-inactivated DELLA transcription regulators. GA promotion of cell elongation required BR signalling, whereas BR or active BZR1 suppressed the GA-deficient dwarf phenotype. DELLAs directly interacted with BZR1 and inhibited BZR1-DNA binding both in vitro and in vivo. Genome-wide analysis defined a BZR1-dependent GA-regulated transcriptome, which is enriched with light-regulated genes and genes involved in cell wall synthesis and photosynthesis/chloroplast function. GA promotion of hypocotyl elongation requires both BZR1 and the phytochrome-interacting factors (PIFs), as well as their common downstream targets encoding the PRE-family helix-loop-helix factors. The results demonstrate that GA releases DELLA-mediated inhibition of BZR1, and that the DELLA-BZR1-PIF4 interaction defines a core transcription module that mediates coordinated growth regulation by GA, BR and light signals.

Original languageEnglish
Pages (from-to)810-817
Number of pages8
JournalNature Cell Biology
Volume14
Issue number8
DOIs
Publication statusPublished - 2012 Aug

ASJC Scopus subject areas

  • Cell Biology

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    Bai, M. Y., Shang, J. X., Oh, E., Fan, M., Bai, Y., Zentella, R., Sun, T. P., & Wang, Z. Y. (2012). Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis. Nature Cell Biology, 14(8), 810-817. https://doi.org/10.1038/ncb2546