Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis

Ming Yi Bai, Jian Xiu Shang, Eunkyoo Oh, Min Fan, Yang Bai, Rodolfo Zentella, Tai Ping Sun, Zhi Yong Wang

Research output: Contribution to journalArticle

285 Citations (Scopus)

Abstract

Brassinosteroid and gibberellin promote many similar developmental responses in plants; however, their relationship remains unclear. Here we show that BR and GA act interdependently through a direct interaction between the BR-Activated BZR1 and GA-inactivated DELLA transcription regulators. GA promotion of cell elongation required BR signalling, whereas BR or active BZR1 suppressed the GA-deficient dwarf phenotype. DELLAs directly interacted with BZR1 and inhibited BZR1-DNA binding both in vitro and in vivo. Genome-wide analysis defined a BZR1-dependent GA-regulated transcriptome, which is enriched with light-regulated genes and genes involved in cell wall synthesis and photosynthesis/chloroplast function. GA promotion of hypocotyl elongation requires both BZR1 and the phytochrome-interacting factors (PIFs), as well as their common downstream targets encoding the PRE-family helix-loop-helix factors. The results demonstrate that GA releases DELLA-mediated inhibition of BZR1, and that the DELLA-BZR1-PIF4 interaction defines a core transcription module that mediates coordinated growth regulation by GA, BR and light signals.

Original languageEnglish
Pages (from-to)810-817
Number of pages8
JournalNature Cell Biology
Volume14
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1
Externally publishedYes

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Brassinosteroids
Phytochrome
Gibberellins
Arabidopsis
Light
Hypocotyl
Photosynthesis
Chloroplasts
Transcriptome
Cell Wall
Genes
Genome
Phenotype
DNA
Growth

ASJC Scopus subject areas

  • Cell Biology

Cite this

Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis. / Bai, Ming Yi; Shang, Jian Xiu; Oh, Eunkyoo; Fan, Min; Bai, Yang; Zentella, Rodolfo; Sun, Tai Ping; Wang, Zhi Yong.

In: Nature Cell Biology, Vol. 14, No. 8, 01.08.2012, p. 810-817.

Research output: Contribution to journalArticle

Bai, MY, Shang, JX, Oh, E, Fan, M, Bai, Y, Zentella, R, Sun, TP & Wang, ZY 2012, 'Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis', Nature Cell Biology, vol. 14, no. 8, pp. 810-817. https://doi.org/10.1038/ncb2546
Bai, Ming Yi ; Shang, Jian Xiu ; Oh, Eunkyoo ; Fan, Min ; Bai, Yang ; Zentella, Rodolfo ; Sun, Tai Ping ; Wang, Zhi Yong. / Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis. In: Nature Cell Biology. 2012 ; Vol. 14, No. 8. pp. 810-817.
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