Breast abscess caused by staphylococcus aureus in 2 adolescent girls with atopic dermatitis

Sung Man Park, Won Sik Choi, Yoon Sun Yoon, Gee Hae Jung, Chang Kyu Lee, So Hyun Ahn, Wonsuck Yoon, Young Yoo

Research output: Contribution to journalArticle

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease in children. Patients with AD experience a high rate of colonization of the skin surface by Staphylococcus aureus. Because of a skin barrier defect, there is a potential risk of staphylococcal invasive infection in patients with AD. Here, we present 2 cases of breast abscess caused by S. aureus in 2 adolescent girls with severe AD. Methicillin-sensitive S. aureus was identified from the breast abscess material. They were treated with appropriate antibiotics, however surgical drainage of the abscess was needed in case 1. Identical strains were found from the breast abscess material as well as the lesional and the nonlesional skin of the patients through matrix-assisted laser desorption/ionization time-of-flight analysis. We characterized the differential abundance of Firmicutes phylum in patients’ skin in microbiota analysis. In particular, S. aureus, a member of Firmicutes, differed significantly between the lesional and the normal-appearing skin. Our cases demonstrate the potential severity of bacterial deep tissue infection in AD and the dysbiosis of skin microbiota may be involved in inflammation in AD.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalKorean Journal of Pediatrics
Volume61
Issue number6
DOIs
Publication statusPublished - 2018 Jun 1

    Fingerprint

Keywords

  • Atopic dermatitis
  • Child
  • Mastitis
  • Microbiome
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this