BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence

Hee Young Jeon, Cheol Gyu Park, Seok Won Ham, Sang Hun Choi, Seon Yong Lee, Jung Yun Kim, Sunyoung Seo, Xiong Jin, Jun Kyum Kim, Kiyoung Eun, Eun Jung Kim, Hyunggee Kim

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Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive and lethal human brain tumors, and the median survival of patients with GBM is only 14 months. Glioblastoma stem cells (GSCs) are regarded as a main cause of GBM recurrence, because of their self-renewal and drug resistance properties. Therefore, targeting GSCs is an important therapeutic strategy for GBM. In this study, we show the effects of BRM270, a compound from natural plant extracts, on GSCs in vitro and GBM recurrence in vivo. BRM270 induced apoptotic cell death and inhibited cell growth and "stemness" both in vitro and in vivo. Combining BRM270 treatment with concurrent chemoradiotherapy (CCRT) dramatically increased mice survival and tumor growth inhibition. Taken together, our results suggested that BRM270 synergizes with CCRT as a therapeutic agent to target GSCs.

Original languageEnglish
Pages (from-to)838-845
Number of pages8
JournalJournal of Medicinal Food
Volume20
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

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Keywords

  • BRM270
  • concurrent chemoradiotherapy
  • glioblastoma multiforme
  • glioblastoma stem cells
  • natural plant extract

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Jeon, H. Y., Park, C. G., Ham, S. W., Choi, S. H., Lee, S. Y., Kim, J. Y., Seo, S., Jin, X., Kim, J. K., Eun, K., Kim, E. J., & Kim, H. (2017). BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence. Journal of Medicinal Food, 20(9), 838-845. https://doi.org/10.1089/jmf.2017.3929