Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors

S. H. Choi, Young Yoo, J. Yu, C. S. Rhee, Y. G. Min, Y. Y. Koh

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: Subjects with allergic rhinitis but no clinical evidence of asthma have greater bronchial hyperresponsiveness (BHR), and several factors have been implicated as its determinants. However, studies in young children are lacking. The aims of this study were to evaluate the prevalence of BHR in young children with allergic rhinitis and to investigate its risk factors. Methods: Methacholine bronchial challenges were performed in 4- to 6-year-old nonasthmatic children with allergic rhinitis (n = 83) and in healthy nonatopic controls (n = 32), using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. Subjects were considered to have BHR when they had end-point concentrations of methacholine ≤8 mg/mL. Clinical and laboratory data in allergic rhinitis patients and a history of allergic diseases in their parents were collected. Results: BHR was observed in 27 subjects with allergic rhinitis (32.5%) and three controls (9.4%). Among subjects with allergic rhinitis, serum total IgE, the number and pattern of skin-prick test responses, blood eosinophil markers, and parental history of allergic rhinitis and atopic dermatitis were not different between the BHR(+) and BHR(-) groups, whereas the persistent type of rhinitis and parental history of asthma were more frequent in the BHR(+) group than in the BHR(-) group. These associations remained significant in a multivariable logistic regression. Conclusions: Young children with allergic rhinitis alone showed an increased prevalence of BHR. Both persistent type of rhinitis and parental history of asthma were significant and independent risk factors for BHR in these children.

Original languageEnglish
Pages (from-to)1051-1056
Number of pages6
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume62
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

Fingerprint

Asthma
Methacholine Chloride
Rhinitis
Auscultation
Allergic Rhinitis
Respiratory Sounds
Atopic Dermatitis
Skin Tests
Eosinophils
Immunoglobulin E
Parents
Logistic Models
Oxygen
Serum

Keywords

  • Allergic rhinitis
  • Bronchial hyperresponsiveness
  • Methacholine
  • Risk factors
  • Young children

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors. / Choi, S. H.; Yoo, Young; Yu, J.; Rhee, C. S.; Min, Y. G.; Koh, Y. Y.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 62, No. 9, 01.09.2007, p. 1051-1056.

Research output: Contribution to journalArticle

@article{a0982043ac2141269c67ccd1bcafa823,
title = "Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors",
abstract = "Background: Subjects with allergic rhinitis but no clinical evidence of asthma have greater bronchial hyperresponsiveness (BHR), and several factors have been implicated as its determinants. However, studies in young children are lacking. The aims of this study were to evaluate the prevalence of BHR in young children with allergic rhinitis and to investigate its risk factors. Methods: Methacholine bronchial challenges were performed in 4- to 6-year-old nonasthmatic children with allergic rhinitis (n = 83) and in healthy nonatopic controls (n = 32), using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. Subjects were considered to have BHR when they had end-point concentrations of methacholine ≤8 mg/mL. Clinical and laboratory data in allergic rhinitis patients and a history of allergic diseases in their parents were collected. Results: BHR was observed in 27 subjects with allergic rhinitis (32.5{\%}) and three controls (9.4{\%}). Among subjects with allergic rhinitis, serum total IgE, the number and pattern of skin-prick test responses, blood eosinophil markers, and parental history of allergic rhinitis and atopic dermatitis were not different between the BHR(+) and BHR(-) groups, whereas the persistent type of rhinitis and parental history of asthma were more frequent in the BHR(+) group than in the BHR(-) group. These associations remained significant in a multivariable logistic regression. Conclusions: Young children with allergic rhinitis alone showed an increased prevalence of BHR. Both persistent type of rhinitis and parental history of asthma were significant and independent risk factors for BHR in these children.",
keywords = "Allergic rhinitis, Bronchial hyperresponsiveness, Methacholine, Risk factors, Young children",
author = "Choi, {S. H.} and Young Yoo and J. Yu and Rhee, {C. S.} and Min, {Y. G.} and Koh, {Y. Y.}",
year = "2007",
month = "9",
day = "1",
doi = "10.1111/j.1398-9995.2007.01403.x",
language = "English",
volume = "62",
pages = "1051--1056",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors

AU - Choi, S. H.

AU - Yoo, Young

AU - Yu, J.

AU - Rhee, C. S.

AU - Min, Y. G.

AU - Koh, Y. Y.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Background: Subjects with allergic rhinitis but no clinical evidence of asthma have greater bronchial hyperresponsiveness (BHR), and several factors have been implicated as its determinants. However, studies in young children are lacking. The aims of this study were to evaluate the prevalence of BHR in young children with allergic rhinitis and to investigate its risk factors. Methods: Methacholine bronchial challenges were performed in 4- to 6-year-old nonasthmatic children with allergic rhinitis (n = 83) and in healthy nonatopic controls (n = 32), using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. Subjects were considered to have BHR when they had end-point concentrations of methacholine ≤8 mg/mL. Clinical and laboratory data in allergic rhinitis patients and a history of allergic diseases in their parents were collected. Results: BHR was observed in 27 subjects with allergic rhinitis (32.5%) and three controls (9.4%). Among subjects with allergic rhinitis, serum total IgE, the number and pattern of skin-prick test responses, blood eosinophil markers, and parental history of allergic rhinitis and atopic dermatitis were not different between the BHR(+) and BHR(-) groups, whereas the persistent type of rhinitis and parental history of asthma were more frequent in the BHR(+) group than in the BHR(-) group. These associations remained significant in a multivariable logistic regression. Conclusions: Young children with allergic rhinitis alone showed an increased prevalence of BHR. Both persistent type of rhinitis and parental history of asthma were significant and independent risk factors for BHR in these children.

AB - Background: Subjects with allergic rhinitis but no clinical evidence of asthma have greater bronchial hyperresponsiveness (BHR), and several factors have been implicated as its determinants. However, studies in young children are lacking. The aims of this study were to evaluate the prevalence of BHR in young children with allergic rhinitis and to investigate its risk factors. Methods: Methacholine bronchial challenges were performed in 4- to 6-year-old nonasthmatic children with allergic rhinitis (n = 83) and in healthy nonatopic controls (n = 32), using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. Subjects were considered to have BHR when they had end-point concentrations of methacholine ≤8 mg/mL. Clinical and laboratory data in allergic rhinitis patients and a history of allergic diseases in their parents were collected. Results: BHR was observed in 27 subjects with allergic rhinitis (32.5%) and three controls (9.4%). Among subjects with allergic rhinitis, serum total IgE, the number and pattern of skin-prick test responses, blood eosinophil markers, and parental history of allergic rhinitis and atopic dermatitis were not different between the BHR(+) and BHR(-) groups, whereas the persistent type of rhinitis and parental history of asthma were more frequent in the BHR(+) group than in the BHR(-) group. These associations remained significant in a multivariable logistic regression. Conclusions: Young children with allergic rhinitis alone showed an increased prevalence of BHR. Both persistent type of rhinitis and parental history of asthma were significant and independent risk factors for BHR in these children.

KW - Allergic rhinitis

KW - Bronchial hyperresponsiveness

KW - Methacholine

KW - Risk factors

KW - Young children

UR - http://www.scopus.com/inward/record.url?scp=34547671125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547671125&partnerID=8YFLogxK

U2 - 10.1111/j.1398-9995.2007.01403.x

DO - 10.1111/j.1398-9995.2007.01403.x

M3 - Article

VL - 62

SP - 1051

EP - 1056

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 9

ER -