Abstract
Aim: Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma, but it is also frequently demonstrated by children and adults with chronic obstructive lung diseases. BHR is usually measured by bronchial challenges using direct or indirect stimuli. The aim of this study was to compare these two types of bronchial challenge in young children with post-infectious bronchiolitis obliterans (BO). Methods: Methacholine and adenosine 5′-monophosphate (AMP) bronchial challenges were performed on preschool children with post-infectious BO (n = 18), those with asthma (n = 23) and in controls (n = 20), using a modified auscultation method. The endpoint was defined as the appearance of wheezing and/or oxygen desaturation. Results: A positive response to methacholine (an endpoint concentration ≤8 mg/ml) was observed in 88.9% (16/18) of the patients with post-infectious BO, but a positive response to AMP (an endpoint concentration ≤200 mg/ml) was observed in only 22.2% (4/18). All patients with asthma responded positively to methacholine, and most (21/23, 91.3%) of them also responded positively to AMP. The majority of the controls were insensitive to both challenges. Conclusion: BHR to methacholine is a frequent, but by no means universal, finding in young children with post-infectious BO, but is usually not accompanied by BHR to AMP.
| Original language | English |
|---|---|
| Pages (from-to) | 56-61 |
| Number of pages | 6 |
| Journal | Acta Paediatrica, International Journal of Paediatrics |
| Volume | 95 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2006 Jan 1 |
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Keywords
- Adenosine 5′-monophosphate (AMP)
- Asthma
- Bronchial hyperresponsiveness
- Methacholine
- Post-infectious bronchiolitis obliterans
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Bronchial responsiveness to methacholine and adenosine 5′- monophosphate (AMP) in young children with post-infectious bronchiolitis obliterans. / Do, Kyun Kim; Yoo, Young; Yu, Jinho; Sun, Hee Choi; Young, Yull Koh.
In: Acta Paediatrica, International Journal of Paediatrics, Vol. 95, No. 1, 01.01.2006, p. 56-61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bronchial responsiveness to methacholine and adenosine 5′- monophosphate (AMP) in young children with post-infectious bronchiolitis obliterans
AU - Do, Kyun Kim
AU - Yoo, Young
AU - Yu, Jinho
AU - Sun, Hee Choi
AU - Young, Yull Koh
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Aim: Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma, but it is also frequently demonstrated by children and adults with chronic obstructive lung diseases. BHR is usually measured by bronchial challenges using direct or indirect stimuli. The aim of this study was to compare these two types of bronchial challenge in young children with post-infectious bronchiolitis obliterans (BO). Methods: Methacholine and adenosine 5′-monophosphate (AMP) bronchial challenges were performed on preschool children with post-infectious BO (n = 18), those with asthma (n = 23) and in controls (n = 20), using a modified auscultation method. The endpoint was defined as the appearance of wheezing and/or oxygen desaturation. Results: A positive response to methacholine (an endpoint concentration ≤8 mg/ml) was observed in 88.9% (16/18) of the patients with post-infectious BO, but a positive response to AMP (an endpoint concentration ≤200 mg/ml) was observed in only 22.2% (4/18). All patients with asthma responded positively to methacholine, and most (21/23, 91.3%) of them also responded positively to AMP. The majority of the controls were insensitive to both challenges. Conclusion: BHR to methacholine is a frequent, but by no means universal, finding in young children with post-infectious BO, but is usually not accompanied by BHR to AMP.
AB - Aim: Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma, but it is also frequently demonstrated by children and adults with chronic obstructive lung diseases. BHR is usually measured by bronchial challenges using direct or indirect stimuli. The aim of this study was to compare these two types of bronchial challenge in young children with post-infectious bronchiolitis obliterans (BO). Methods: Methacholine and adenosine 5′-monophosphate (AMP) bronchial challenges were performed on preschool children with post-infectious BO (n = 18), those with asthma (n = 23) and in controls (n = 20), using a modified auscultation method. The endpoint was defined as the appearance of wheezing and/or oxygen desaturation. Results: A positive response to methacholine (an endpoint concentration ≤8 mg/ml) was observed in 88.9% (16/18) of the patients with post-infectious BO, but a positive response to AMP (an endpoint concentration ≤200 mg/ml) was observed in only 22.2% (4/18). All patients with asthma responded positively to methacholine, and most (21/23, 91.3%) of them also responded positively to AMP. The majority of the controls were insensitive to both challenges. Conclusion: BHR to methacholine is a frequent, but by no means universal, finding in young children with post-infectious BO, but is usually not accompanied by BHR to AMP.
KW - Adenosine 5′-monophosphate (AMP)
KW - Asthma
KW - Bronchial hyperresponsiveness
KW - Methacholine
KW - Post-infectious bronchiolitis obliterans
UR - http://www.scopus.com/inward/record.url?scp=29944447738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29944447738&partnerID=8YFLogxK
U2 - 10.1080/08035250500323756
DO - 10.1080/08035250500323756
M3 - Article
VL - 95
SP - 56
EP - 61
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
SN - 0803-5253
IS - 1
ER -