Bronchiolitis obliterans organizing pneumonia in the patient with non-small cell lung cancer treated with docetaxel/cisplatin chemotherapy

A case report

Ae Ran Kim, Tae Young Kim, Young Min Lee, Seung Heon Lee, Soo Jin Jung, Hyun Kyung Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 60-year-old man was diagnosed with stage IV squamous cell carcinoma of lung and treated with weekly doses of docetaxel and cisplatin. Tumor mass and mediastinal lymphadenopathy disappeared after 4.5 cycles of chemotherapy. At one week post final chemotherapy, the patients developed sudden shortness of breath. New, multifocal infiltrations developed on both lungs without definitive evidence of infection. Despite administration of broad spectrum antibiotics, the lung lesion did not improve, so bronchoalveolar lavage and computed tomography-guided lung biopsy were performed. The proportion of lymphocytes was increased markedly and histopathology revealed squamous cell carcinoma combined with bronchiolitis obliterans organizing pneumonia. After high dose corticosteroid therapy, dyspnea and the newly developed consolidation had decreased slightly. However, dyspnea and hypoxemia increased again because of aggravated lung cancer since chemotherapy had stopped. Chemotherapy couldn' t be restarted due to the poor performance status of the patient. Later, patient died of respiratory failure from poor general condition and progression of lung cancer. Copyright

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalTuberculosis and Respiratory Diseases
Volume69
Issue number4
DOIs
Publication statusPublished - 2010 Oct 1
Externally publishedYes

Fingerprint

docetaxel
Cryptogenic Organizing Pneumonia
Non-Small Cell Lung Carcinoma
Cisplatin
Dyspnea
Drug Therapy
Lung
Squamous Cell Carcinoma
Lung Neoplasms
Bronchoalveolar Lavage
Respiratory Insufficiency
Adrenal Cortex Hormones
Tomography
Lymphocytes
Anti-Bacterial Agents
Biopsy
Infection

Keywords

  • Cryptogenic organizing pneumonia
  • Docetaxel
  • Drug therapy
  • Lung neoplasms

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Bronchiolitis obliterans organizing pneumonia in the patient with non-small cell lung cancer treated with docetaxel/cisplatin chemotherapy : A case report. / Kim, Ae Ran; Kim, Tae Young; Lee, Young Min; Lee, Seung Heon; Jung, Soo Jin; Lee, Hyun Kyung.

In: Tuberculosis and Respiratory Diseases, Vol. 69, No. 4, 01.10.2010, p. 293-297.

Research output: Contribution to journalArticle

@article{5a7c73e91c584712b39bdf7a00e88521,
title = "Bronchiolitis obliterans organizing pneumonia in the patient with non-small cell lung cancer treated with docetaxel/cisplatin chemotherapy: A case report",
abstract = "A 60-year-old man was diagnosed with stage IV squamous cell carcinoma of lung and treated with weekly doses of docetaxel and cisplatin. Tumor mass and mediastinal lymphadenopathy disappeared after 4.5 cycles of chemotherapy. At one week post final chemotherapy, the patients developed sudden shortness of breath. New, multifocal infiltrations developed on both lungs without definitive evidence of infection. Despite administration of broad spectrum antibiotics, the lung lesion did not improve, so bronchoalveolar lavage and computed tomography-guided lung biopsy were performed. The proportion of lymphocytes was increased markedly and histopathology revealed squamous cell carcinoma combined with bronchiolitis obliterans organizing pneumonia. After high dose corticosteroid therapy, dyspnea and the newly developed consolidation had decreased slightly. However, dyspnea and hypoxemia increased again because of aggravated lung cancer since chemotherapy had stopped. Chemotherapy couldn' t be restarted due to the poor performance status of the patient. Later, patient died of respiratory failure from poor general condition and progression of lung cancer. Copyright",
keywords = "Cryptogenic organizing pneumonia, Docetaxel, Drug therapy, Lung neoplasms",
author = "Kim, {Ae Ran} and Kim, {Tae Young} and Lee, {Young Min} and Lee, {Seung Heon} and Jung, {Soo Jin} and Lee, {Hyun Kyung}",
year = "2010",
month = "10",
day = "1",
doi = "10.4046/trd.2010.69.4.293",
language = "English",
volume = "69",
pages = "293--297",
journal = "Tuberculosis and Respiratory Diseases",
issn = "1738-3536",
publisher = "The Korean Academy of Tuberculosis and Respiratory Diseases",
number = "4",

}

TY - JOUR

T1 - Bronchiolitis obliterans organizing pneumonia in the patient with non-small cell lung cancer treated with docetaxel/cisplatin chemotherapy

T2 - A case report

AU - Kim, Ae Ran

AU - Kim, Tae Young

AU - Lee, Young Min

AU - Lee, Seung Heon

AU - Jung, Soo Jin

AU - Lee, Hyun Kyung

PY - 2010/10/1

Y1 - 2010/10/1

N2 - A 60-year-old man was diagnosed with stage IV squamous cell carcinoma of lung and treated with weekly doses of docetaxel and cisplatin. Tumor mass and mediastinal lymphadenopathy disappeared after 4.5 cycles of chemotherapy. At one week post final chemotherapy, the patients developed sudden shortness of breath. New, multifocal infiltrations developed on both lungs without definitive evidence of infection. Despite administration of broad spectrum antibiotics, the lung lesion did not improve, so bronchoalveolar lavage and computed tomography-guided lung biopsy were performed. The proportion of lymphocytes was increased markedly and histopathology revealed squamous cell carcinoma combined with bronchiolitis obliterans organizing pneumonia. After high dose corticosteroid therapy, dyspnea and the newly developed consolidation had decreased slightly. However, dyspnea and hypoxemia increased again because of aggravated lung cancer since chemotherapy had stopped. Chemotherapy couldn' t be restarted due to the poor performance status of the patient. Later, patient died of respiratory failure from poor general condition and progression of lung cancer. Copyright

AB - A 60-year-old man was diagnosed with stage IV squamous cell carcinoma of lung and treated with weekly doses of docetaxel and cisplatin. Tumor mass and mediastinal lymphadenopathy disappeared after 4.5 cycles of chemotherapy. At one week post final chemotherapy, the patients developed sudden shortness of breath. New, multifocal infiltrations developed on both lungs without definitive evidence of infection. Despite administration of broad spectrum antibiotics, the lung lesion did not improve, so bronchoalveolar lavage and computed tomography-guided lung biopsy were performed. The proportion of lymphocytes was increased markedly and histopathology revealed squamous cell carcinoma combined with bronchiolitis obliterans organizing pneumonia. After high dose corticosteroid therapy, dyspnea and the newly developed consolidation had decreased slightly. However, dyspnea and hypoxemia increased again because of aggravated lung cancer since chemotherapy had stopped. Chemotherapy couldn' t be restarted due to the poor performance status of the patient. Later, patient died of respiratory failure from poor general condition and progression of lung cancer. Copyright

KW - Cryptogenic organizing pneumonia

KW - Docetaxel

KW - Drug therapy

KW - Lung neoplasms

UR - http://www.scopus.com/inward/record.url?scp=78649338003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649338003&partnerID=8YFLogxK

U2 - 10.4046/trd.2010.69.4.293

DO - 10.4046/trd.2010.69.4.293

M3 - Article

VL - 69

SP - 293

EP - 297

JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

SN - 1738-3536

IS - 4

ER -