TY - JOUR
T1 - Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis
AU - Kim, Chang Keun
AU - Kim, Sang Woo
AU - Kim, Young Ki
AU - Kang, Hee
AU - Yu, Jinho
AU - Yoo, Young
AU - Koh, Young Yull
PY - 2005/5
Y1 - 2005/5
N2 - Objective: In this study, we measured the levels of eosinophil cationic protein (ECP) and interleukin (IL)-8 in bronchoalveolar lavage (BAL) fluid from patients with acute asthma and acute bronchiolitis, to determine any similarities or dissimilarities in the profiles of these biochemical markers in the two diseases. Methods: BAL fluids were obtained from children with acute asthma (n = 16), infants with acute bronchiolitis caused by respiratory syncytial virus (n = 18), and control subjects (n = 14). Children with asthma were selected to be free of viral infection. BAL cell counts and differentials were determined, and ECP and IL-8 levels were measured by radioimmunoassay and ELISA, respectively. Results: ECP levels in BAL fluids were significantly higher in the asthma group than in the bronchiolitis (P < 0.01) or control (P < 0.0001) groups. However, IL-8 levels were significantly higher in the bronchiolitis group than in the asthma (P < 0.01) or control (P < 0.001) groups. IL-8 levels in the asthma group and ECP levels in the bronchiolitis group were similar to those of the control group. Conclusion: This difference in profiles of ECP and IL-8 in acute asthma and acute bronchiolitis, together with a different inflammatory cell pattern, suggests that the nature of the inflammatory process within the lower respiratory tract may be distinctive in these two diseases.
AB - Objective: In this study, we measured the levels of eosinophil cationic protein (ECP) and interleukin (IL)-8 in bronchoalveolar lavage (BAL) fluid from patients with acute asthma and acute bronchiolitis, to determine any similarities or dissimilarities in the profiles of these biochemical markers in the two diseases. Methods: BAL fluids were obtained from children with acute asthma (n = 16), infants with acute bronchiolitis caused by respiratory syncytial virus (n = 18), and control subjects (n = 14). Children with asthma were selected to be free of viral infection. BAL cell counts and differentials were determined, and ECP and IL-8 levels were measured by radioimmunoassay and ELISA, respectively. Results: ECP levels in BAL fluids were significantly higher in the asthma group than in the bronchiolitis (P < 0.01) or control (P < 0.0001) groups. However, IL-8 levels were significantly higher in the bronchiolitis group than in the asthma (P < 0.01) or control (P < 0.001) groups. IL-8 levels in the asthma group and ECP levels in the bronchiolitis group were similar to those of the control group. Conclusion: This difference in profiles of ECP and IL-8 in acute asthma and acute bronchiolitis, together with a different inflammatory cell pattern, suggests that the nature of the inflammatory process within the lower respiratory tract may be distinctive in these two diseases.
KW - Acute asthma
KW - Acute bronchiolitis
KW - Bronchoalveolar lavage
KW - Eosinophil cationic protein
KW - Interleukin-8
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U2 - 10.1111/j.1365-2222.2005.02224.x
DO - 10.1111/j.1365-2222.2005.02224.x
M3 - Article
C2 - 15898980
AN - SCOPUS:20044391702
SN - 0954-7894
VL - 35
SP - 591
EP - 597
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
IS - 5
ER -