@article{f7d9c0da8a2241c19fd510e1bfa9c68f,
title = "Burden of Human papillomavirus (HPV)-related disease and potential impact of HPV vaccines in the Republic of Korea",
abstract = "Background: We aimed to review the burden and the potential impact of human papillomavirus (HPV) vaccines on HPV-related diseases in the Republic of Korea and to discuss cervical cancer prevention practices in this country. Methods: Cancer burden statistics were retrieved from GLOBOCAN-2018 and Statistics Korea. HPV disease burden was assessed via systematic review. Vaccine types relative contribution (RC) was estimated using data from an international project using formalin-fixed paraffin-embedded specimens. Results: Despite a downtrend in cervical cancer in recent years, Korean rates remain high. In contrast, oropharyngeal cancer incidence has gradually increased and other anogenital cancers remain rare. In Korea, HPV prevalence in general population is around 20%. In cervical cancer, RC of HPVs 16/18 (74.0%) increased to 92.0% when including HPVs 31/33/45/52/58. Limited information was available for other HPV-related cancer sites. Regarding prevention, since the inclusion of the HPV vaccine into the National Immunization Program, almost half (49%) of the target cohort in 2016 had received the first dose of vaccine. Further, percentage of women screened with pap has increased from 41.1%-2009 to 53.0%-2016. Conclusions: HPV-related disease burden in Korea is significant. Results suggest that the combination of effective and high coverage HPV vaccination and screening programmes could substantially impact on HPV-related disease in Korea.",
keywords = "Burden, Cancer, Cervical cancer screening, Human papillomavirus, Papillomavirus vaccine, Republic of Korea",
author = "Kim, {Young Tak} and Beatriz Serrano and Lee, {Jae Kwan} and Hyunju Lee and Lee, {Shin Wha} and Crystal Freeman and Oh, {Jin Kyoung} and Laia Alemany and Bosch, {Francesc Xavier} and Laia Bruni",
note = "Funding Information: The analysis here presented has been supported by Merck & Co., Inc., who had no role in the data collection, analysis, interpretation of the results and submission of the article for publication This work was partially supported by grants from the Instituto de Salud Carlos III-ISCIII (Spanish Government) co funded by FEDER funds/European Regional Development Fund (ERDF) - a way to build Europe (PI18/01137, PI17/00123, PI15/01205, CIBERESP (CB06/02/0073), CIBERONC (CB16/12/00401)), With the support of the Secretariat for Universities and Research of the Department of Business and Knowledge of the Government of Catalonia. Grants to support the activities of research groups (SGR 2017-2019), Grant number 2017SGR1718 and 2017SGR1085. Funding Information: The analysis here presented has been supported by Merck & Co., Inc. The authors would like to specifically acknowledge the support by Gonzalo Perez MD; Smita Kothari Ph.D.; Anuj Walia; Hee Yoon Park and Jin Oh Kim, although they had no role in the data collection, analysis, interpretation of the results and submission of the article for publication. Funding Information: Francesc X. Bosch has received scientific advisory board fees, speaker{\textquoteright}s fees, or travel grants from GlaxoSmithKline, Merck, Sanofi Pasteur MSD, Genticel, Hologic and Roche; and unrestricted institutional research grants from GlaxoSmithKline, Merck, Qiagen, and Roche. Cancer Epidemiology Research Program (Francesc X. Bosch, Laia Alemany, Laia Bruni, Beatriz Serrano) has received unrestricted research grants from Merck and co. Hyunju Lee receives honorarium for lectures from Merck, Sanofi Pasteur MSD and GlaxoSmithKline. Funding Information: The analysis here presented has been supported by Merck & Co., Inc., who had no role in the data collection, analysis, interpretation of the results and submission of the article for publication This work was partially supported by grants from the Instituto de Salud Carlos III-ISCIII (Spanish Government) co funded by FEDER funds/ European Regional Development Fund (ERDF) - a way to build Europe ( PI18/01137 , PI17/00123 , PI15/01205 , CIBERESP (CB06/02/0073), CIBERONC (CB16/12/00401)), With the support of the Secretariat for Universities and Research of the Department of Business and Knowledge of the Government of Catalonia. Grants to support the activities of research groups (SGR 2017-2019), Grant number 2017SGR1718 and 2017SGR1085. Publisher Copyright: {\textcopyright} 2018",
year = "2019",
month = jun,
doi = "10.1016/j.pvr.2018.12.002",
language = "English",
volume = "7",
pages = "26--42",
journal = "Papillomavirus Research",
issn = "2405-8521",
publisher = "Elsevier BV",
}
