Burden of illness, quality of life, and healthcare utilization among patients with herpes zoster in South Korea: A prospective clinical-epidemiological study

Haejun Song, Jeongdeuk Lee, Muhyung Lee, Won Suk Choi, Jung Hyun Choi, Mi Suk Lee, Mahdi Hashemi, Emmanouil Rampakakis, Kosuke Kawai, Ron White, Camilo Acosta, John S. Sampalis, Hee Jin Cheong

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    Objectives: To assess the herpes zoster (HZ) disease burden, including the severity and duration of HZ-associated pain, its impact on quality of life (QoL), and healthcare resource utilization (HCRU) in a South Korean clinical setting. Methods: Patients aged ≥50 years were followed prospectively for ≤6 months. Based on the duration of their episode at enrolment, cases were classified as incident (<7 days) or prevalent (≥7 days). HZ pain and discomfort were measured with the HZ Severity of Illness (HZ-SOI) severity-by-duration composite score. Results: One hundred fifty-one patients (69.5% prevalent cases) were enrolled. Prodrome pain was experienced by 68.2% of patients, of whom 95.1% experienced moderate-to-severe pain; post-herpetic neuralgia was experienced by 38.4%. Prevalent disease, higher acute pain, and older age were significant predictors of greater HZ-SOI, while use of antivirals was associated with decreased HZ-SOI. HZ-associated pain was associated with reduced QoL and affected all daily living activities (particularly mood, life enjoyment, general activities, and sleep), resulting in significant HCRU, including primary care doctor, specialist, or physiotherapist consultations, hospitalizations, and emergency department visits. Conclusion: Severe morbidity, impaired QoL, and significant HCRU are associated with HZ in South Korea, especially in older patients, supporting the need for early intervention and preventive strategies to reduce the HZ-associated disease burden.

    Original languageEnglish
    Pages (from-to)23-30
    Number of pages8
    JournalInternational Journal of Infectious Diseases
    Volume20
    Issue number1
    DOIs
    Publication statusPublished - 2014 Mar

    Keywords

    • Burden of illness
    • Herpes zoster
    • Observational
    • Pain
    • Quality of life
    • South Korea

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Infectious Diseases

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