Butylated Hydroxyanisole Exerts Neurotoxic Effects by Promoting Cytosolic Calcium Accumulation and Endoplasmic Reticulum Stress in Astrocytes

Agriculture & Biology

• animals 3%
• antioxidants 5%
• astrocytes 79%
• biomarkers 7%
• brain 11%
• butylated hydroxyanisole 88%
• calcium 41%
• caspase-3 10%
• caspase-9 12%
• caspases 10%
• cell cycle checkpoints 10%
• cells 2%
• chelating agents 8%
• cytochrome c 9%
• cytotoxicity 7%
• Danio rerio 16%
• embryo (animal) 5%
• endoplasmic reticulum stress 85%
• genetically modified organisms 6%
• gonads 7%
• hepatotoxicity 9%
• inflammation 7%
• learning 7%
• mitogen-activated protein kinase 8%
• nerve tissue 7%
• neuroglia 8%
• nutritional support 11%
• phosphatidylinositol 3-kinase 10%
• pro-apoptotic proteins 24%
• protein kinases 7%
• protein synthesis 6%
• proteins 8%
• regulatory proteins 9%
• sleep 9%

Medicine & Life Sciences

• 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 11%
• Animals 4%
• Antioxidants 6%
• Apoptosis Regulatory Proteins 19%
• Astrocytes 60%
• Biomarkers 5%
• Brain 8%
• Butylated Hydroxyanisole 100%
• Calcium 44%
• Calcium Chelating Agents 11%
• Caspase 3 7%
• Caspase 9 9%
• Caspases 8%
• Cell Cycle Checkpoints 7%
• Cytochromes c 8%
• Down-Regulation 11%
• Embryonic Structures 6%
• Endoplasmic Reticulum Stress 73%
• Genitalia 7%
• Glial Fibrillary Acidic Protein 9%
• Heat-Shock Proteins 17%
• Inflammation 4%
• Learning 6%
• Liver 4%
• Mitogen-Activated Protein Kinase 1 9%
• Mitogen-Activated Protein Kinase 3 9%
• Nutritional Support 9%
• Phosphatidylinositol 3-Kinase 8%
• Proteins 3%
• Proto-Oncogene Proteins c-akt 9%
• Signal Transduction 6%
• Sleep 6%
• Therapeutics 2%
• Zebrafish 16%

Chemical Compounds

• Antiapoptotic 13%
• Antioxidant Agent 7%
• Biological Marker 8%
• Butylated Hydroxyanisole 96%
• Calcium(0) 50%
• Chelating Agent 9%
• Cytochrome 8%
• Neurotoxic 83%
• Phosphoinositide 12%
• Proliferative 12%
• Protein 27%