C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome

Kyung Mook Choi, Soon Young Hwang, Ho Cheol Hong, Sae Jeong Yang, Hae Yoon Choi, Hye-Jin Yoo, Kwan Woo Lee, Moon Suk Nam, Yong Soo Park, Jeong Taek Woo, Young Seol Kim, Dong Seop Choi, Byung Soo Youn, Sei-Hyun Baik

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors.

Original languageEnglish
Pages (from-to)2932-2936
Number of pages5
JournalDiabetes
Volume61
Issue number11
DOIs
Publication statusPublished - 2012 Nov 1

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Type 2 Diabetes Mellitus
Proteins
Glucose
Pulse Wave Analysis
Glomerular Filtration Rate
Ankle
C-Reactive Protein
Insulin Resistance
Arm
pigment epithelium-derived factor
Prediabetic State
Adipokines
Waist-Hip Ratio
Adiponectin
Alanine Transaminase
Innate Immunity
HDL Cholesterol
Triglycerides
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. / Choi, Kyung Mook; Hwang, Soon Young; Hong, Ho Cheol; Yang, Sae Jeong; Choi, Hae Yoon; Yoo, Hye-Jin; Lee, Kwan Woo; Nam, Moon Suk; Park, Yong Soo; Woo, Jeong Taek; Kim, Young Seol; Choi, Dong Seop; Youn, Byung Soo; Baik, Sei-Hyun.

In: Diabetes, Vol. 61, No. 11, 01.11.2012, p. 2932-2936.

Research output: Contribution to journalArticle

Choi, KM, Hwang, SY, Hong, HC, Yang, SJ, Choi, HY, Yoo, H-J, Lee, KW, Nam, MS, Park, YS, Woo, JT, Kim, YS, Choi, DS, Youn, BS & Baik, S-H 2012, 'C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome', Diabetes, vol. 61, no. 11, pp. 2932-2936. https://doi.org/10.2337/db12-0217
Choi, Kyung Mook ; Hwang, Soon Young ; Hong, Ho Cheol ; Yang, Sae Jeong ; Choi, Hae Yoon ; Yoo, Hye-Jin ; Lee, Kwan Woo ; Nam, Moon Suk ; Park, Yong Soo ; Woo, Jeong Taek ; Kim, Young Seol ; Choi, Dong Seop ; Youn, Byung Soo ; Baik, Sei-Hyun. / C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. In: Diabetes. 2012 ; Vol. 61, No. 11. pp. 2932-2936.
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AU - Yang, Sae Jeong

AU - Choi, Hae Yoon

AU - Yoo, Hye-Jin

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AU - Woo, Jeong Taek

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