C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome

Kyung Mook Choi, Soon Young Hwang, Ho Cheol Hong, Sae Jeong Yang, Hae Yoon Choi, Hye Jin Yoo, Kwan Woo Lee, Moon Suk Nam, Yong Soo Park, Jeong Taek Woo, Young Seol Kim, Dong Seop Choi, Byung Soo Youn, Sei Hyun Baik

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67 Citations (Scopus)

Abstract

Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors.

Original languageEnglish
Pages (from-to)2932-2936
Number of pages5
JournalDiabetes
Volume61
Issue number11
DOIs
Publication statusPublished - 2012 Nov

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Choi, K. M., Hwang, S. Y., Hong, H. C., Yang, S. J., Choi, H. Y., Yoo, H. J., Lee, K. W., Nam, M. S., Park, Y. S., Woo, J. T., Kim, Y. S., Choi, D. S., Youn, B. S., & Baik, S. H. (2012). C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. Diabetes, 61(11), 2932-2936. https://doi.org/10.2337/db12-0217