Calcium-Binding Polymer-Coated Poly(lactide-co-glycolide) Microparticles for Sustained Release of Quorum Sensing Inhibitors to Prevent Biofilm Formation on Hydroxyapatite Surfaces

Minji Kang, Sungwhan Kim, Heejin Kim, Youngjun Song, Dongwook Jung, Sunah Kang, Ji-Hun Seo, Sohee Nam, Yan Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Quorum sensing (QS) inhibitor-based therapy is an attractive strategy to inhibit bacterial biofilm formation without excessive induction of antibiotic resistance. Thus, we designed Ca 2+ -binding poly(lactide-co-glycolide) (PLGA) microparticles that can maintain a sufficient concentration of QS inhibitors around hydroxyapatite (HA) surfaces in order to prevent biofilm formation on HA-based dental or bone tissues or implants and, therefore, subsequent pathogenesis. Poly(butyl methacrylate-co-methacryloyloxyethyl phosphate) (PBMP) contains both Ca 2+ -binding phosphomonoester groups and PLGA-interacting butyl groups. The PBMP-coated PLGA (PLGA/PBMP) microparticles exhibited superior adhesion to HA surfaces without altering the sustained release properties of uncoated PLGA microparticles. PLGA/PBMP microparticle-encapsulating furanone C-30, a representative QS inhibitor, effectively inhibited the growth of Streptococcus mutans and its ability to form biofilms on HA surface for prolonged periods of up to 100 h, which was much longer than either furanone C-30 in its free form or when encapsulated in noncoated PLGA microparticles.

Original languageEnglish
Pages (from-to)7686-7694
Number of pages9
JournalACS Applied Materials and Interfaces
Volume11
Issue number8
DOIs
Publication statusPublished - 2019 Feb 27

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Keywords

  • biofilm formation
  • calcium binding polymer
  • PLGA microparticles
  • quorum sensing inhibitors
  • sustained drug delivery

ASJC Scopus subject areas

  • Materials Science(all)

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