Calcium channels: the potential therapeutic targets for inflammatory bone destruction of rheumatoid arthritis

Robin Park, Jong Dae Ji

    Research output: Contribution to journalReview articlepeer-review

    5 Citations (Scopus)

    Abstract

    Introduction: Inflammatory bone resorption causes progressive joint destruction which ultimately leads to functional disability in rheumatoid arthritis (RA). The primary cell responsible for bone resorption is the osteoclast, which means it is a potential therapeutic target against bone destruction. In fact, experimental and clinical findings suggest that blockade of osteoclast differentiation and function is highly effective in inhibiting bone destruction in RA. Discussion and conclusion: In this report, we show several lines of experimental evidence which suggest that a variety of Ca2+ channels are essential in osteoclast differentiation and function, and present a hypothesis that modulation of Ca2+ channels is a highly effective therapeutic strategy in preventing osteoclast-induced structural damage in RA.

    Original languageEnglish
    Pages (from-to)347-354
    Number of pages8
    JournalInflammation Research
    Volume65
    Issue number5
    DOIs
    Publication statusPublished - 2016 May 1

    Keywords

    • Calcium channel
    • Inflammation
    • Osteoclast
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Immunology
    • Pharmacology

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