Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism

Hye Jeong Lee, U. Hyoung Seo, Woo Young Kim, Sang Uk Woo, Jae Bok Lee

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Objective: This retrospective study investigated the characteristics of secondary hyperparathyroidism (SHPT) by examining the presence of the calcium-sensing receptor (CaSR) and the rate of cell proliferation and apoptosis in parathyroid glands. Methods: Eighteen diffuse and 57 nodular hyperplastic parathyroid glands from 24 patients with SHPT were compared with 14 primary adenomas and 33 normal parathyroid glands using immunohistochemical staining of CaSR and a marker of proliferative activity (Ki67 antigen). Apoptosis was measured using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling assay. Results: The mean±SE labelling index (LI) of CaSR (12.8%±1.5%) in nodular hyperplasia was significantly lower than that in normal parathyroid glands (26.8%±0.8%), whereas the mean±SE LI of CaSR in diffuse hyperplasia was similar to that in normal parathyroid glands (23.3%±1.8%). The mean±SE LI of Ki67 antigen was significantly higher in primary adenoma and nodular hyperplasia than in normal parathyroid glands. Conclusion: These results indicate that downregulation of CaSR, and a higher rate of proliferation over apoptosis, could contribute to the pathological progression of SHPT.

    Original languageEnglish
    Pages (from-to)97-105
    Number of pages9
    JournalJournal of International Medical Research
    Volume41
    Issue number1
    DOIs
    Publication statusPublished - 2013 Feb

    Keywords

    • Calcium-sensing receptor
    • Chronic kidney disease
    • Parathyroid gland
    • Parathyroid hormone
    • Secondary hyperparathyroidism

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Biochemistry, medical

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