TY - JOUR
T1 - Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae
AU - Choi, Joon Seok
AU - Choi, Kyung Mi
AU - Lee, Cheol Koo
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (Nos. 2008-0061063 and 2009-0084110 ) to C.K.L., as well as by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. 351-2009-1-C00063 ) to J.S.C.
PY - 2011/6/3
Y1 - 2011/6/3
N2 - Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.
AB - Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.
KW - Caloric restriction
KW - Growth rate
KW - Lifespan extension
KW - Mitochondrial electron transport chain
KW - Mitochondrial membrane potential
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=79957896111&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2011.05.008
DO - 10.1016/j.bbrc.2011.05.008
M3 - Article
C2 - 21575595
AN - SCOPUS:79957896111
SN - 0006-291X
VL - 409
SP - 308
EP - 314
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -