Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae

Joon Seok Choi, Kyung Mi Choi, Cheol Koo Lee

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.

Original languageEnglish
Pages (from-to)308-314
Number of pages7
JournalBiochemical and biophysical research communications
Volume409
Issue number2
DOIs
Publication statusPublished - 2011 Jun 3

Keywords

  • Caloric restriction
  • Growth rate
  • Lifespan extension
  • Mitochondrial electron transport chain
  • Mitochondrial membrane potential
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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