Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis

Seung Bae Rho, Hyun Jung Byun, Sang Yoon Park, Taehoon Chun

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalCancer Letters
Volume271
Issue number2
DOIs
Publication statusPublished - 2008 Nov 28

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Keywords

  • Angiogenesis
  • Apoptosis
  • Calpain 6
  • Endothelial cell
  • Ovarian carcinoma cell

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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