Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis

Seung Bae Rho, Hyun Jung Byun, Sang Yoon Park, Taehoon Chun

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalCancer Letters
Volume271
Issue number2
DOIs
Publication statusPublished - 2008 Nov 28

Fingerprint

Calpain
Carcinogenesis
Apoptosis
Uterine Cervical Neoplasms
Tissue
Endothelial cells
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Cisplatin
Cells

Keywords

  • Angiogenesis
  • Apoptosis
  • Calpain 6
  • Endothelial cell
  • Ovarian carcinoma cell

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. / Rho, Seung Bae; Byun, Hyun Jung; Park, Sang Yoon; Chun, Taehoon.

In: Cancer Letters, Vol. 271, No. 2, 28.11.2008, p. 306-313.

Research output: Contribution to journalArticle

Rho, Seung Bae ; Byun, Hyun Jung ; Park, Sang Yoon ; Chun, Taehoon. / Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. In: Cancer Letters. 2008 ; Vol. 271, No. 2. pp. 306-313.
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