Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system

Sun Dongbang, Hyun Mi Jeon, Min Hee Lee, Weon Sup Shin, Joon Kook Kwon, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A galactose-appended camptothecin prodrug was newly synthesized. The prodrug preferentially entered a hepatoma cell line due to the galactose unit and the drug release triggered by disulfide-bond cleavage via reaction with glutathione was visualized on the basis of fluorescence changes of the naphthalimide moiety. The prodrug entered the cells via receptor-mediated endocytosis and released drug molecules into lysosomes, however, the released drug molecules failed to show significant anticancer activity, probably due to lysosomal hydrolysis of their lactone ring converting them to an inactive carboxylate form.

Original languageEnglish
Pages (from-to)18744-18748
Number of pages5
JournalRSC Advances
Volume4
Issue number36
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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