Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system

Sun Dongbang, Hyun Mi Jeon, Min Hee Lee, Weon Sup Shin, Joon Kook Kwon, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A galactose-appended camptothecin prodrug was newly synthesized. The prodrug preferentially entered a hepatoma cell line due to the galactose unit and the drug release triggered by disulfide-bond cleavage via reaction with glutathione was visualized on the basis of fluorescence changes of the naphthalimide moiety. The prodrug entered the cells via receptor-mediated endocytosis and released drug molecules into lysosomes, however, the released drug molecules failed to show significant anticancer activity, probably due to lysosomal hydrolysis of their lactone ring converting them to an inactive carboxylate form.

Original languageEnglish
Pages (from-to)18744-18748
Number of pages5
JournalRSC Advances
Volume4
Issue number36
DOIs
Publication statusPublished - 2014 Jan 1

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Camptothecin
Prodrugs
Galactose
Cells
Molecules
Naphthalimides
Pharmaceutical Preparations
Hydrolysis
Fluorescence
Lactones
Disulfides
Glutathione
Drug Delivery Systems

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system. / Dongbang, Sun; Jeon, Hyun Mi; Lee, Min Hee; Shin, Weon Sup; Kwon, Joon Kook; Kang, Chulhun; Kim, Jong Seung.

In: RSC Advances, Vol. 4, No. 36, 01.01.2014, p. 18744-18748.

Research output: Contribution to journalArticle

Dongbang, S, Jeon, HM, Lee, MH, Shin, WS, Kwon, JK, Kang, C & Kim, JS 2014, 'Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system', RSC Advances, vol. 4, no. 36, pp. 18744-18748. https://doi.org/10.1039/c4ra02588a
Dongbang, Sun ; Jeon, Hyun Mi ; Lee, Min Hee ; Shin, Weon Sup ; Kwon, Joon Kook ; Kang, Chulhun ; Kim, Jong Seung. / Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system. In: RSC Advances. 2014 ; Vol. 4, No. 36. pp. 18744-18748.
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