Can mean platelet volume predict coronary vasospasm?

Cheol Ung Choi, Hong Seog Seo, Yun Kyung Kim, Jin Oh Na, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Seung Woon Rha, Chang Gyu Park, Dong Joo Oh

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Mean platelet volume (MPV) is an index of platelet function that reflects platelet production rate and sensitivity to activation. The relationship between MPV and coronary vasospasm has not been previously studied. In this study, we aimed to evaluate this relationship. A total of 696 patients (age 55.20 ± 12.26, male 46.4%, female 53.6%) with typical or atypical angina who underwent diagnostic coronary angiography (CAG) and an acetylcholine (Ach)-provocation test were enrolled. Each patient was assigned to either an Ach-induced coronary vasospasm group (n = 183) or a control group (n = 513). We compared MPV between the two groups. MPV and the platelet count showed a negative correlation (r = -0.289, p < 0.001). MPV was higher in the Ach-induced coronary vasospasm group than in the control group (9.03 ± 1.37 fl and 8.69 ± 1.25 fl, respectively, p = 0.002). In multivariate analysis, MPV independently predicted Ach-induced coronary vasospasm (OR = 1.188, p = 0.018). This study identified high MPV as an independent risk factor for Ach-induced coronary vasospasm.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalPlatelets
Volume22
Issue number3
DOIs
Publication statusPublished - 2011 May

Keywords

  • Ach-induced coronary vasospasm
  • Mean platelet volume

ASJC Scopus subject areas

  • Hematology

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