Can prostate-specific antigen kinetics before prostate biopsy predict the malignant potential of prostate cancer?

Sang Jin Kim, Tae Yoong Jeong, Dae Seon Yoo, Jinsung Park, Seok Cho, Seok Ho Kang, Sang Hyub Lee, Seung Hyun Jeon, Tchun Yong Lee, Sung Yul Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To predict the malignant potential of prostate cancer (PCa) according to prostate-specific antigen velocity (PSAV), PSA density (PSAD), free/total PSA ratio (%fPSA), and digital rectal examination (DRE). Materials and Methods: From January 2009 to December 2012, 548 adult male patients were diagnosed with PCa by prostate biopsy at four hospitals in Korea. We retrospectively analyzed 155 adult male patients with an initial PSA level ≤10 ng/mL and whose PSA levels had been checked more than two times at least 6 months before they had been diagnosed with PCa, with test intervals of more than 3 months. Patients with a urinary tract infection, and patients who had previously undergone cystoscopy or surgery of the prostate were excluded. We separated patients into two groups according to Gleason sum [Gleason sum ≤7 (n=134) or Gleason sum ≥8 (n=21)] and the presence of extracapsular invasion [organ confined (n=129) or extracapsular invasion (n=26)]. Differences between the groups were compared. Results: The group with a Gleason sum ≥8 or extracapsular invasion of PCa showed high PSAV and significantly lower %fPSA. There were no significant differences in PSAD and the presence of an abnormality on DRE between two groups. Conclusion: In PCa patients treated with other therapies besides prostatectomy, a high PSA velocity and a low %fPSA may predict high grade PCa with a Gleason sum ≥8 or the presence of extracapsular invasion.

Original languageEnglish
Pages (from-to)1492-1496
Number of pages5
JournalYonsei Medical Journal
Volume56
Issue number6
DOIs
Publication statusPublished - 2015 Nov 1

Fingerprint

Prostate-Specific Antigen
Prostate
Prostatic Neoplasms
Biopsy
Digital Rectal Examination
Cystoscopy
Korea
Prostatectomy
Urinary Tract Infections

Keywords

  • Gleason score
  • Prostate-specific antigen
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Can prostate-specific antigen kinetics before prostate biopsy predict the malignant potential of prostate cancer? / Kim, Sang Jin; Jeong, Tae Yoong; Yoo, Dae Seon; Park, Jinsung; Cho, Seok; Kang, Seok Ho; Lee, Sang Hyub; Jeon, Seung Hyun; Lee, Tchun Yong; Park, Sung Yul.

In: Yonsei Medical Journal, Vol. 56, No. 6, 01.11.2015, p. 1492-1496.

Research output: Contribution to journalArticle

Kim, SJ, Jeong, TY, Yoo, DS, Park, J, Cho, S, Kang, SH, Lee, SH, Jeon, SH, Lee, TY & Park, SY 2015, 'Can prostate-specific antigen kinetics before prostate biopsy predict the malignant potential of prostate cancer?', Yonsei Medical Journal, vol. 56, no. 6, pp. 1492-1496. https://doi.org/10.3349/ymj.2015.56.6.1492
Kim, Sang Jin ; Jeong, Tae Yoong ; Yoo, Dae Seon ; Park, Jinsung ; Cho, Seok ; Kang, Seok Ho ; Lee, Sang Hyub ; Jeon, Seung Hyun ; Lee, Tchun Yong ; Park, Sung Yul. / Can prostate-specific antigen kinetics before prostate biopsy predict the malignant potential of prostate cancer?. In: Yonsei Medical Journal. 2015 ; Vol. 56, No. 6. pp. 1492-1496.
@article{14b1e41fdd984141843931dc5a1d8efc,
title = "Can prostate-specific antigen kinetics before prostate biopsy predict the malignant potential of prostate cancer?",
abstract = "Purpose: To predict the malignant potential of prostate cancer (PCa) according to prostate-specific antigen velocity (PSAV), PSA density (PSAD), free/total PSA ratio ({\%}fPSA), and digital rectal examination (DRE). Materials and Methods: From January 2009 to December 2012, 548 adult male patients were diagnosed with PCa by prostate biopsy at four hospitals in Korea. We retrospectively analyzed 155 adult male patients with an initial PSA level ≤10 ng/mL and whose PSA levels had been checked more than two times at least 6 months before they had been diagnosed with PCa, with test intervals of more than 3 months. Patients with a urinary tract infection, and patients who had previously undergone cystoscopy or surgery of the prostate were excluded. We separated patients into two groups according to Gleason sum [Gleason sum ≤7 (n=134) or Gleason sum ≥8 (n=21)] and the presence of extracapsular invasion [organ confined (n=129) or extracapsular invasion (n=26)]. Differences between the groups were compared. Results: The group with a Gleason sum ≥8 or extracapsular invasion of PCa showed high PSAV and significantly lower {\%}fPSA. There were no significant differences in PSAD and the presence of an abnormality on DRE between two groups. Conclusion: In PCa patients treated with other therapies besides prostatectomy, a high PSA velocity and a low {\%}fPSA may predict high grade PCa with a Gleason sum ≥8 or the presence of extracapsular invasion.",
keywords = "Gleason score, Prostate-specific antigen, Prostatic neoplasms",
author = "Kim, {Sang Jin} and Jeong, {Tae Yoong} and Yoo, {Dae Seon} and Jinsung Park and Seok Cho and Kang, {Seok Ho} and Lee, {Sang Hyub} and Jeon, {Seung Hyun} and Lee, {Tchun Yong} and Park, {Sung Yul}",
year = "2015",
month = "11",
day = "1",
doi = "10.3349/ymj.2015.56.6.1492",
language = "English",
volume = "56",
pages = "1492--1496",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "6",

}

TY - JOUR

T1 - Can prostate-specific antigen kinetics before prostate biopsy predict the malignant potential of prostate cancer?

AU - Kim, Sang Jin

AU - Jeong, Tae Yoong

AU - Yoo, Dae Seon

AU - Park, Jinsung

AU - Cho, Seok

AU - Kang, Seok Ho

AU - Lee, Sang Hyub

AU - Jeon, Seung Hyun

AU - Lee, Tchun Yong

AU - Park, Sung Yul

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Purpose: To predict the malignant potential of prostate cancer (PCa) according to prostate-specific antigen velocity (PSAV), PSA density (PSAD), free/total PSA ratio (%fPSA), and digital rectal examination (DRE). Materials and Methods: From January 2009 to December 2012, 548 adult male patients were diagnosed with PCa by prostate biopsy at four hospitals in Korea. We retrospectively analyzed 155 adult male patients with an initial PSA level ≤10 ng/mL and whose PSA levels had been checked more than two times at least 6 months before they had been diagnosed with PCa, with test intervals of more than 3 months. Patients with a urinary tract infection, and patients who had previously undergone cystoscopy or surgery of the prostate were excluded. We separated patients into two groups according to Gleason sum [Gleason sum ≤7 (n=134) or Gleason sum ≥8 (n=21)] and the presence of extracapsular invasion [organ confined (n=129) or extracapsular invasion (n=26)]. Differences between the groups were compared. Results: The group with a Gleason sum ≥8 or extracapsular invasion of PCa showed high PSAV and significantly lower %fPSA. There were no significant differences in PSAD and the presence of an abnormality on DRE between two groups. Conclusion: In PCa patients treated with other therapies besides prostatectomy, a high PSA velocity and a low %fPSA may predict high grade PCa with a Gleason sum ≥8 or the presence of extracapsular invasion.

AB - Purpose: To predict the malignant potential of prostate cancer (PCa) according to prostate-specific antigen velocity (PSAV), PSA density (PSAD), free/total PSA ratio (%fPSA), and digital rectal examination (DRE). Materials and Methods: From January 2009 to December 2012, 548 adult male patients were diagnosed with PCa by prostate biopsy at four hospitals in Korea. We retrospectively analyzed 155 adult male patients with an initial PSA level ≤10 ng/mL and whose PSA levels had been checked more than two times at least 6 months before they had been diagnosed with PCa, with test intervals of more than 3 months. Patients with a urinary tract infection, and patients who had previously undergone cystoscopy or surgery of the prostate were excluded. We separated patients into two groups according to Gleason sum [Gleason sum ≤7 (n=134) or Gleason sum ≥8 (n=21)] and the presence of extracapsular invasion [organ confined (n=129) or extracapsular invasion (n=26)]. Differences between the groups were compared. Results: The group with a Gleason sum ≥8 or extracapsular invasion of PCa showed high PSAV and significantly lower %fPSA. There were no significant differences in PSAD and the presence of an abnormality on DRE between two groups. Conclusion: In PCa patients treated with other therapies besides prostatectomy, a high PSA velocity and a low %fPSA may predict high grade PCa with a Gleason sum ≥8 or the presence of extracapsular invasion.

KW - Gleason score

KW - Prostate-specific antigen

KW - Prostatic neoplasms

UR - http://www.scopus.com/inward/record.url?scp=84944031072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944031072&partnerID=8YFLogxK

U2 - 10.3349/ymj.2015.56.6.1492

DO - 10.3349/ymj.2015.56.6.1492

M3 - Article

VL - 56

SP - 1492

EP - 1496

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 6

ER -