Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment

Iljin Kim, Sanga Choi, Seongkyeong Yoo, Mingyu Lee, In San Kim

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Solid cancers are composed of malignant cells and their surrounding matrix components. Hypoxia plays a critical role in shaping the tumor microenvironment that contributes to cancer progression and treatment failure. Cancer-associated fibroblasts (CAFs) are one of the most prominent components of the tumor microenvironment. CAFs are highly sensitive to hypoxia and participates in the crosstalk with cancer cells. Hypoxic CAFs modulate several mechanisms that induce cancer malignancy, such as extracellular matrix (ECM) remodeling, immune evasion, metabolic reprogramming, angiogenesis, metastasis, and drug resistance. Key signaling molecules regulating CAFs in hypoxia include transforming growth factor (TGF-β) and hypoxia-inducible factors (HIFs). In this article, we summarize the mechanisms underlying the hypoxic regulation of CAFs and how hypoxic CAFs affect cancer development and progression. We also discuss the potential therapeutic strategies focused on targeting CAFs in the hypoxic tumor microenvironment.

Original languageEnglish
Article number3321
JournalCancers
Volume14
Issue number14
DOIs
Publication statusPublished - 2022 Jul 1

Keywords

  • cancer
  • cancer-associated fibroblast
  • hypoxia
  • tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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