Cancer Mechanobiology: Microenvironmental Sensing and Metastasis

Geonhui Lee, Seong Beom Han, Jung Hwan Lee, Hae Won Kim, Dong Hwee Kim

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

The cellular microenvironment plays an important role in regulating cancer progress. Cancer can physically and chemically remodel its surrounding extracellular matrix (ECM). Critical cellular behaviors such as recognition of matrix geometry and rigidity, cell polarization and motility, cytoskeletal reorganization, and proliferation can be changed as a consequence of these ECM alternations. Here, we present an overview of cancer mechanobiology in detail, focusing on cancer microenvironmental sensing of exogenous cues and quantification of cancer-substrate interactions. In addition, mechanics of metastasis classified with tumor progression will be discussed. The mechanism underlying cancer mechanosensation and tumor progression may provide new insights into therapeutic strategies to alleviate cancer malignancy.

Original languageEnglish
Pages (from-to)3735-3752
Number of pages18
JournalACS Biomaterials Science and Engineering
Volume5
Issue number8
DOIs
Publication statusPublished - 2019 Aug 12

Keywords

  • mechanosensation
  • mechanotransduction
  • metastatic potential
  • physics of cancer
  • tumor microenvironment

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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