TY - JOUR
T1 - Cancer risk in patients with Parkinson's disease in South Korea
T2 - A nationwide, population-based cohort study
AU - Park, Joo Hyun
AU - Kim, Do Hoon
AU - Park, Yong Gyu
AU - Kwon, Do Young
AU - Choi, Moonyoung
AU - Jung, Jin Hyung
AU - Han, Kyungdo
N1 - Funding Information:
This work was supported by a grant from the Korea University Ansan Hospital in South Korea. The funding body had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
This work was supported by a grant from the Korea University Ansan Hospital in South Korea. The funding body had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/8
Y1 - 2019/8
N2 - Introduction: The association between Parkinson's disease (PD) and cancer development is controversial, especially in Asia. Therefore, we conducted a nationwide population-based cohort study to assess the overall cancer risk and risk for specific cancers in patients with PD in Korea. Methods: Using data from the Korean National Health Insurance Database, we analysed 52,009 patients diagnosed with PD between 2010 and 2015 and 260,045 individuals without PD. Patients previously diagnosed with cancer were excluded. The age- and sex-matched cohorts were followed up until 2016 for cancer development. Cox proportional hazards regression models were used to evaluate the relationship between PD and cancer. Results: Patients with PD had a lower overall cancer risk (hazard ratio [HR], 0.78; 95% confidence interval [CI], 0.74–0.82) after adjustment for multiple covariates during 2,022,852.6 person-years of follow-up. Patients with PD showed significantly lower risk of laryngeal cancer (HR, 0.45; 95% CI, 0.21–0.84), gastric cancer (HR, 0.72; 95% CI, 0.63–0.82), colorectal cancer (HR, 0.675; 95% CI, 0.60–0.76), liver cancer (HR, 0.80; 95% CI, 0.67–0.95), pancreatic cancer (HR, 0.75; 95% CI, 0.62–0.91), lung cancer (HR, 0.73; 95% CI, 0.63–0.84), leukaemia (HR, 0.49; 95% CI, 0.24–0.89), uterine cervical cancer (HR, 0.64; 95% CI, 0.40–0.99) and prostate cancer (HR, 0.78; 95% CI, 0.66–0.91). Conclusion: This nationwide population-based cohort study revealed that patients with PD had lower overall cancer risk and lower risk of specific cancers. Contrary to the results of the recent Asian study, this large cohort study revealed that patients with PD were less likely to develop cancer than those without PD in Korea. Our results were consistent with those of previous Western studies, despite differences in ethnicity and environment.
AB - Introduction: The association between Parkinson's disease (PD) and cancer development is controversial, especially in Asia. Therefore, we conducted a nationwide population-based cohort study to assess the overall cancer risk and risk for specific cancers in patients with PD in Korea. Methods: Using data from the Korean National Health Insurance Database, we analysed 52,009 patients diagnosed with PD between 2010 and 2015 and 260,045 individuals without PD. Patients previously diagnosed with cancer were excluded. The age- and sex-matched cohorts were followed up until 2016 for cancer development. Cox proportional hazards regression models were used to evaluate the relationship between PD and cancer. Results: Patients with PD had a lower overall cancer risk (hazard ratio [HR], 0.78; 95% confidence interval [CI], 0.74–0.82) after adjustment for multiple covariates during 2,022,852.6 person-years of follow-up. Patients with PD showed significantly lower risk of laryngeal cancer (HR, 0.45; 95% CI, 0.21–0.84), gastric cancer (HR, 0.72; 95% CI, 0.63–0.82), colorectal cancer (HR, 0.675; 95% CI, 0.60–0.76), liver cancer (HR, 0.80; 95% CI, 0.67–0.95), pancreatic cancer (HR, 0.75; 95% CI, 0.62–0.91), lung cancer (HR, 0.73; 95% CI, 0.63–0.84), leukaemia (HR, 0.49; 95% CI, 0.24–0.89), uterine cervical cancer (HR, 0.64; 95% CI, 0.40–0.99) and prostate cancer (HR, 0.78; 95% CI, 0.66–0.91). Conclusion: This nationwide population-based cohort study revealed that patients with PD had lower overall cancer risk and lower risk of specific cancers. Contrary to the results of the recent Asian study, this large cohort study revealed that patients with PD were less likely to develop cancer than those without PD in Korea. Our results were consistent with those of previous Western studies, despite differences in ethnicity and environment.
KW - Cancer
KW - Epidemiology
KW - Malignant tumour
KW - Neoplasms
KW - Neurodegenerative disease
KW - Parkinson disease
UR - http://www.scopus.com/inward/record.url?scp=85067398568&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2019.04.033
DO - 10.1016/j.ejca.2019.04.033
M3 - Article
C2 - 31229950
AN - SCOPUS:85067398568
SN - 0959-8049
VL - 117
SP - 5
EP - 13
JO - European Journal of Cancer
JF - European Journal of Cancer
ER -
