Cancer theranosis using mono-disperse, mesoporous gold nanoparticles obtained via a robust, high-yield synthetic methodology

Taeksu Lee, Doyeon Bang, Yong Wook Chang, Yuna Choi, Kwang Yeol Park, Aram Oh, Seungmin Han, Sun Hee Kim, Kwangyeol Lee, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Porous noble metal nanoparticles exhibit many attractive nanoplasmonic features, and these structures have potential applications in many fields. However, such applications have been hindered by a lack of synthetic methods with the ability to mass-produce mono-disperse nanoparticles. Current synthetic approaches to porous gold nanostructure fabrication involve galvanic replacement approaches or electrochemical deposition methods that are generally limited by stringent multi-step protocols and relatively low yields. Here, we introduce the facile synthesis of scalable, mono-disperse, mesoporous gold nanoparticles (MPGNs) using an acidic emulsification method. This method facilitates high synthetic yields (>93%) and tunable particle sizes (130-400 nm). MPGNs exhibit enhanced payloads of gadolinium (Gd), a contrast agent for magnetic resonance imaging. Additionally, they permit photo-thermal conversion under near-infrared light (NIR) irradiation due to the increased surface area to volume ratio and the unique, structure-mediated LSPR effect. Specifically, MPGNs fabricated using our method provided Gd payloads 2-4 orders of magnitude greater than previously reported theranostic nano-probes. We believe that our novel synthetic technique will not only contribute to large-scale production of homogeneous porous gold nanoparticles, but will also promote further research in porous noble metal nanostructures.

Original languageEnglish
Pages (from-to)13554-13561
Number of pages8
JournalRSC Advances
Volume6
Issue number16
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

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    Lee, T., Bang, D., Chang, Y. W., Choi, Y., Park, K. Y., Oh, A., Han, S., Kim, S. H., Lee, K., Suh, J. S., Huh, Y. M., & Haam, S. (2016). Cancer theranosis using mono-disperse, mesoporous gold nanoparticles obtained via a robust, high-yield synthetic methodology. RSC Advances, 6(16), 13554-13561. https://doi.org/10.1039/c5ra24772a