Candida spondylodiscitis with epidural abscess treated with voriconazole

Ji Yun Noh, Yeon Heo Jung, Suk Choi Won, Mi J. Yu, Joon-Young Song, Hee-Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Candida spondylodiscitis with epidural abscess is rarely reported and known to be the late complication of candidemia. A 48-years-old man presented with 4 weeks of progressively aggravating low back pain. He had a history of fungemia caused by Candida albicans 4 months earlier, for which he had been treated successfully with systemic fluconazole. The MRI of lumbar spine demonstrated the spondylodiscitis with multiple epidural abscesses at the L2/3 level. Along with the surgical interventions including abscess drainage, the intravenous amphotericin B administration was begun. Culture of drained pus yielded the growth of Candida albicans. After therapy with parenteral amphotericin B for 2 weeks followed by oral fluconazole for 8 weeks, the back pain resolved. However the low back pain and inflammation relapsed during oral fluconazole therapy. Thereafter oral voriconazole had been administered for 24 weeks and the patient showed complete recovery and no recurrence.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalKorean Journal of Medical Mycology
Volume14
Issue number3
Publication statusPublished - 2009 Sep 1

Fingerprint

Epidural Abscess
Discitis
Fluconazole
Candida
Amphotericin B
Low Back Pain
Candida albicans
Fungemia
Candidemia
Suppuration
Back Pain
Abscess
Drainage
Spine
Inflammation
Recurrence
Therapeutics
Growth
Voriconazole

Keywords

  • Candida
  • Spondylodiscitis
  • Voriconazole

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Candida spondylodiscitis with epidural abscess treated with voriconazole. / Noh, Ji Yun; Jung, Yeon Heo; Won, Suk Choi; Yu, Mi J.; Song, Joon-Young; Cheong, Hee-Jin; Kim, Woo Joo.

In: Korean Journal of Medical Mycology, Vol. 14, No. 3, 01.09.2009, p. 145-149.

Research output: Contribution to journalArticle

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AB - Candida spondylodiscitis with epidural abscess is rarely reported and known to be the late complication of candidemia. A 48-years-old man presented with 4 weeks of progressively aggravating low back pain. He had a history of fungemia caused by Candida albicans 4 months earlier, for which he had been treated successfully with systemic fluconazole. The MRI of lumbar spine demonstrated the spondylodiscitis with multiple epidural abscesses at the L2/3 level. Along with the surgical interventions including abscess drainage, the intravenous amphotericin B administration was begun. Culture of drained pus yielded the growth of Candida albicans. After therapy with parenteral amphotericin B for 2 weeks followed by oral fluconazole for 8 weeks, the back pain resolved. However the low back pain and inflammation relapsed during oral fluconazole therapy. Thereafter oral voriconazole had been administered for 24 weeks and the patient showed complete recovery and no recurrence.

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