Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

Soyeon Jeong, Min Jee Jo, Hye Kyeong Yun, Dae Yeong Kim, Bo Ram Kim, Jung Lim Kim, Seong Hye Park, Yoo Jin Na, Yoon A. Jeong, Bu Gyeom Kim, Hassan Ashktorab, Duane T. Smoot, Jun Young Heo, Jeongsu Han, Sun Il Lee, Han Do Kim, Dae Hyun Kim, Sang Cheul Oh, Dae Hee Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.

Original languageEnglish
Article number846
JournalCell Death and Disease
Volume10
Issue number11
DOIs
Publication statusPublished - 2019 Nov 1

ASJC Scopus subject areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research

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    Jeong, S., Jo, M. J., Yun, H. K., Kim, D. Y., Kim, B. R., Kim, J. L., Park, S. H., Na, Y. J., Jeong, Y. A., Kim, B. G., Ashktorab, H., Smoot, D. T., Heo, J. Y., Han, J., Il Lee, S., Do Kim, H., Kim, D. H., Oh, S. C., & Lee, D. H. (2019). Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer. Cell Death and Disease, 10(11), [846]. https://doi.org/10.1038/s41419-019-2001-7