CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells

Eun Soo Lee, Kyung Ok Uhm, Yun Mi Lee, MyungSuk Han, MyungSik Lee, Ji Man Park, Pann Ghill Suh, Sun-Hwa Park, Hyeon Soo Kim

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Abstract

Caffeic acid phenethyl ester (CAPE), a flavonoid-like compound, is one of the major components of honeybee propolis. In the present study, we investigated the metabolic effects of CAPE in skeletal muscle cells and found that CAPE stimulated glucose uptake in differentiated L6 rat myoblast cells and also activated AMPK (AMP-activated protein kinase). In addition, the inhibition of AMPK blocked CAPE-induced glucose uptake, and CAPE activated the Akt pathway in a PI3K (phosphoinositide 3-kinase)-dependent manner. Furthermore, CAPE enhanced both insulin-mediated Akt activation and glucose uptake. In summary, our results suggest that CAPE may have beneficial roles in glucose metabolism via stimulation of the AMPK pathway.

Original languageEnglish
Pages (from-to)854-858
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume361
Issue number4
DOIs
Publication statusPublished - 2007 Oct 5

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Keywords

  • Akt
  • AMPK
  • CAPE
  • Glucose uptake

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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