Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation

Hyoung Chun Kim, Wang Kee Jhoo, Won Ki Kim, Eun Joo Shin, Mi Ae Cheon, Chan Young Shin, Kwang Ho Ko

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We examined the effects of a non-opioid antitussive, carbetapentane (CB) on kainic acid (KA)-induced neurotoxicity in rats. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4 to 5 h. CB (12.5 and 25 mg/kg, i.p.) pretreatment consistently and in a dose-dependent manner reduced the KA-induced seizures, mortality, and marked loss of cells in regions CA1 and CA3 of the hippocampus. Consistently, CB pretreatment also significantly attenuated the KA-induced increase in Fos-related antigen immunoreactivity in the hippocampus. In contrast, pretreatment with the σ-1 receptor antagonist BD1047 (1 and 2 mg/kg, i.p.) blocked, in a dose-related manner, the neuroprotection afforded by CB. These results suggest that CB provides neuroprotection against KA insult via σ-1 receptor modulation.

Original languageEnglish
Pages (from-to)915-922
Number of pages8
JournalLife Sciences
Volume69
Issue number8
DOIs
Publication statusPublished - 2001 Jul 13
Externally publishedYes

Keywords

  • Anticonvulsant
  • Carbetapentane
  • Fos-related antigen immunoreactivity
  • Hippocampus
  • Kainic acid
  • Neuroprotection
  • Seizures
  • σ-1 receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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