Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation

Hyoung Chun Kim, Wang K. Jhoo, Won-Ki Kim, Eun J. Shin, Mi A. Cheon, Chan Young Shin, Kwang H. Ko

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We examined the effects of a non-opioid antitussive, carbetapentane (CB) on kainic acid (KA)-induced neurotoxicity in rats. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4 to 5 h. CB (12.5 and 25 mg/kg, i.p.) pretreatment consistently and in a dose-dependent manner reduced the KA-induced seizures, mortality, and marked loss of cells in regions CA1 and CA3 of the hippocampus. Consistently, CB pretreatment also significantly attenuated the KA-induced increase in Fos-related antigen immunoreactivity in the hippocampus. In contrast, pretreatment with the σ-1 receptor antagonist BD1047 (1 and 2 mg/kg, i.p.) blocked, in a dose-related manner, the neuroprotection afforded by CB. These results suggest that CB provides neuroprotection against KA insult via σ-1 receptor modulation.

Original languageEnglish
Pages (from-to)915-922
Number of pages8
JournalLife Sciences
Volume69
Issue number8
DOIs
Publication statusPublished - 2001 Jul 13
Externally publishedYes

Fingerprint

Kainic Acid
Seizures
Modulation
Hippocampus
Antitussive Agents
Proto-Oncogene Proteins c-fos
Rats
carbetapentane
Mortality
Neuroprotection

Keywords

  • σ-1 receptor
  • Anticonvulsant
  • Carbetapentane
  • Fos-related antigen immunoreactivity
  • Hippocampus
  • Kainic acid
  • Neuroprotection
  • Seizures

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kim, H. C., Jhoo, W. K., Kim, W-K., Shin, E. J., Cheon, M. A., Shin, C. Y., & Ko, K. H. (2001). Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation. Life Sciences, 69(8), 915-922. https://doi.org/10.1016/S0024-3205(01)01181-X

Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation. / Kim, Hyoung Chun; Jhoo, Wang K.; Kim, Won-Ki; Shin, Eun J.; Cheon, Mi A.; Shin, Chan Young; Ko, Kwang H.

In: Life Sciences, Vol. 69, No. 8, 13.07.2001, p. 915-922.

Research output: Contribution to journalArticle

Kim, HC, Jhoo, WK, Kim, W-K, Shin, EJ, Cheon, MA, Shin, CY & Ko, KH 2001, 'Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation', Life Sciences, vol. 69, no. 8, pp. 915-922. https://doi.org/10.1016/S0024-3205(01)01181-X
Kim, Hyoung Chun ; Jhoo, Wang K. ; Kim, Won-Ki ; Shin, Eun J. ; Cheon, Mi A. ; Shin, Chan Young ; Ko, Kwang H. / Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation. In: Life Sciences. 2001 ; Vol. 69, No. 8. pp. 915-922.
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